中国中药杂志2026，Vol.51Issue(14)：3929-3938,10.DOI:10.19540/j.cnki.cjcmm.20260408.302
地龙蚓激酶的药理作用及其新型制剂技术分析与思考
Analysis and reflection on pharmacological effects and novel formulation technologies of lumbrokinase from Pheretima
摘要
Abstract
Lumbrokinase,a serine protease complex extracted from Pheretima,possesses specific fibrinolytic activity and is clinically used for thrombolytic therapy in cardiovascular and cerebrovascular diseases.Due to its low bleeding risk profile,novel formulation technologies have significantly enhanced its therapeutic efficacy in acute thrombotic diseases.This study discussed the physicochemical properties,absorption properties,pharmacological effects,formulation strategies,and existing challenges of lumbrokinase,providing a comprehensive analysis for its future application and development.关键词
蚓激酶/理化特性/吸收特性/药理作用/新型制剂技术Key words
lumbrokinase/physicochemical property/absorption property/pharmacological effect/novel formulation technology引用本文复制引用
罗文宇,赵飞艳,黄俊峰,张潇文,黄歆雅,傅艺,江婉,李文帅,岳鹏飞..地龙蚓激酶的药理作用及其新型制剂技术分析与思考[J].中国中药杂志,2026,51(14):3929-3938,10.基金项目
江西省赣鄱英才计划创新高端人才项目(gpyc20250055) （gpyc20250055）
2025年度江西省研究生创新专项(YC2025-S211) （YC2025-S211）
