中国中药杂志2026，Vol.51Issue(15)：4293-4302,10.DOI:10.19540/j.cnki.cjcmm.20260428.501
中药及其有效成分治疗少弱精子症的作用机制研究进展
Research progress on mechanisms of TCM and its active components in treatment of oligoasthenozoospermia
摘要
Abstract
Oligoasthenozoospermia(OAS)is one of the major types of male infertility.Its pathogenesis involves multiple factors,including oxidative stress,inflammatory responses,endocrine disorders,mitochondrial dysfunction,and epigenetic abnormalities.Although modern medical treatments can partially improve semen parameters and spermatogenic function,they are often limited by unstable efficacy,strong treatment dependence,high recurrence rates,and notable adverse effects.Under the guidance of syndrome differentiation-based treatment and a holistic perspective,TCM,based on the core theories that the kidney governs reproduction and essence and blood share a common source,intervenes through multiple approaches such as tonifying the kidney and replenishing essence,reinforcing Qi and nourishing blood,removing blood stasis and dredging collaterals,and regulating Qi movement,thereby systematically improving the pathological state of OAS.In recent years,a large number of studies have confirmed that TCMs and their active components can not only significantly improve sperm concentration,motility,and morphological quality,but also enhance DNA integrity and mitochondrial function,promote testicular tissue repair,and optimize the spermatogenic microenvironment.In addition,they exert systemic regulatory effects by modulating redox homeostasis,restoring endocrine balance,and improving energy metabolism.Owing to their multi-target actions,low toxicity,and relatively stable efficacy,TCMs demonstrate unique advantages in the prevention and treatment of male reproductive disorders.This article reviews recent research progress on TCM in the treatment of OAS,summarizing its therapeutic characteristics and biological basis,with the aim of providing a theoretical foundation for the modernization research and clinical application of TCM interventions in male infertility.关键词
少弱精子症/中医药/活性成分/氧化应激/炎症反应Key words
oligoasthenozoospermia/TCM/active component/oxidative stress/inflammatory response引用本文复制引用
李生龙,李喜香,周九云,赵永强,梁永林,卢刚刚,殷鹏东,金广炜,管聪聪,龚美胜..中药及其有效成分治疗少弱精子症的作用机制研究进展[J].中国中药杂志,2026,51(15):4293-4302,10.基金项目
2025年医疗服务与保障能力提升(中医药传承与发展部分)中央补助资金预算项目(甘财社[2024]118号) （中医药传承与发展部分）
国家自然科学基金项目(82460897) （82460897）
甘肃省自然科学基金项目(26JRRA775) （26JRRA775）
甘肃省联合科研基金项目(25JRRA1227) （25JRRA1227）
