中国中药杂志2026，Vol.51Issue(16)：4517-4536,20.DOI:10.19540/j.cnki.cjcmm.20260522.401
中医药数字人:中药整合药理学2.0的创新引擎
TCM digital human:an innovation engine driving TCM integrative pharmacology 2.0
摘要
Abstract
As the primary carrier of clinical treatment in traditional Chinese medicine(TCM),TCM formulae require elucidation of the interaction laws between their chemical substance basis and biological activities,which represents a key scientific issue in TCM re-search.The"TCM integrative pharmacology"theory previously proposed by our team has become an important paradigm in modern TCM research.However,current studies still face several limitations,including a static analytical perspective,insufficient spatiotem-poral information,and unclear mechanisms of cross-organ coordinated regulation.Based on these challenges,this paper further propo-ses the innovative concept of a"TCM digital human".Guided by the integrative pharmacology research paradigm,and drawing on ad-vanced technologies such as virtual cells and virtual physiological human systems,this framework integrates artificial intelligence and multiscale modeling approaches to construct a computable virtual life system with TCM characteristics,ranging from virtual cells and virtual organs to a digital human.This system provides key support for the digital representation of TCM theory and for the scientific elucidation of the mechanisms underlying the therapeutic effects of TCM formulae.关键词
中药方剂/中医药数字人/整合药理学/虚拟生理人/虚拟细胞Key words
TCM formulae/TCM digital human/integrative pharmacology/virtual physiological human/virtual cell引用本文复制引用
许海玉,李森,滕丹,张明波,赵彦辉,王萍,杨洪军..中医药数字人:中药整合药理学2.0的创新引擎[J].中国中药杂志,2026,51(16):4517-4536,20.基金项目
国家重点研发计划项目(2023YFC2308200) （2023YFC2308200）
国家自然科学基金区域创新发展联合基金项目(U25A20167) （U25A20167）
中央级公益性科研院所基本科研业务费专项(ZXKT25041) （ZXKT25041）
