中国中药杂志2026，Vol.51Issue(16)：4569-4580,12.DOI:10.19540/j.cnki.cjcmm.20260518.201
关黄柏抗炎活性成分及其作用机制研究进展
Anti-inflammatory active components and mechanisms of Phellodendri Amurensis Cortex:a review
摘要
Abstract
Phellodendri Amurensis Cortex is the dried bark of Phellodendron amurense(Rutaceae).It has the effects of clearing heat and drying dampness,purging fire and eliminating steaming,and detoxifying and treating sores.Clinically,it is commonly used for inflammatory diseases associated with dampness-heat diarrhea,dysentery,sores,ulcers,and toxic swellings.Modern studies have shown that Phellodendri Amurensis Cortex contains various bioactive components including alkaloids,limonoids,and phenolic acids.Among them,berberine,phellodendrine,and chlorogenic acid can inhibit key inflammatory signaling pathways,regulate inflammasome activation,restore the balance between oxidative stress and inflammation,and modulate immune cell polarization,thereby constructing a synergistic anti-inflammatory network characterized by multiple pathways and multiple targets.This article systematically reviews relevant domestic and international studies published over the past decade and summarizes the main anti-inflammatory active components of Phellodendri Amurensis Cortex and their synergistic mechanisms of action,providing a theoretical basis and research perspectives for the development of innovative anti-inflammatory drugs and the clinical application of Phellodendri Amurensis Cortex.关键词
关黄柏/抗炎/活性成分/小檗碱/作用机制Key words
Phellodendri Amurensis Cortex/anti-inflammation/active components/berberine/mechanism of action引用本文复制引用
李先娜,李梓桐,田信彪,杨波,王志刚,赵永厚,张宁..关黄柏抗炎活性成分及其作用机制研究进展[J].中国中药杂志,2026,51(16):4569-4580,12.基金项目
国家自然科学基金青年科学基金项目(82204690) （82204690）
中国博士后科学基金第17批特别资助项目(2024T170257) （2024T170257）
黑龙江省自然科学基金联合引导项目(LH2023H069) （LH2023H069）
黑龙江省博士后科学基金项目(LBH-Z24030) （LBH-Z24030）
黑龙江省中医药经典普及化研究专项课题(ZYW2022-065) （ZYW2022-065）
2022年度黑龙江省省属高等学校基本科研业务费科研项目(2022PT03) （2022PT03）
2022年度省教育科学规划重点课题(GJB1422248) （GJB1422248）
黑龙江中医药大学科研基金项目(青年科技创新能力培养计划)(2024XJJ-QNCX012) （青年科技创新能力培养计划）
