中国中药杂志2026，Vol.51Issue(16)：4623-4633,11.DOI:10.19540/j.cnki.cjcmm.20260330.401
香豆素类化合物的药理作用、生物合成及制造研究进展
Pharmacological effects,biosynthesis,and production of coumarin compounds:a review
摘要
Abstract
Coumarins mainly include simple coumarins,furanocoumarins,and pyranocoumarins.These compounds exhibit diverse biological activities,including anticoagulant,antibacterial,antitumor,and antioxidant effects,and thus possess high value for drug development.At present,coumarins are mainly obtained through traditional plant extraction methods.In recent years,synthetic biology has emerged as a new approach for the sustainable production of natural products.This article reviews the pharmacological effects,biosynthetic pathways,and biomanufacturing methods of different types of coumarins.It focuses on strategies for improving coumarin production,including the application of enzyme engineering based on directed evolution to modify rate-limiting enzymes and thereby enhance catalytic efficiency;the use of metabolic engineering to remodel metabolic flux,strengthen precursor supply,and weaken competing pathways,allowing more carbon flux to be directed toward target products;and the optimization of fermentation parameters through fermentation engineering to improve the viability of engineered strains and increase the yield of target compounds.These studies provide important references for the green,efficient,and sustainable production of coumarins,and are conducive to promoting the development of new coumarin-based drugs.关键词
香豆素/药理作用/生物合成途径/代谢调控/生物制造Key words
coumarin/pharmaceutical effects/biosynthetic pathway/metabolic regulation/bioproduction引用本文复制引用
陈旺彬,杨加增,李宁,訾佳辰..香豆素类化合物的药理作用、生物合成及制造研究进展[J].中国中药杂志,2026,51(16):4623-4633,11.基金项目
国家重点研发计划项目(2024YFA0919900) （2024YFA0919900）
国家自然科学基金面上项目(82373764) （82373764）
