中国中西医结合杂志2026，Vol.46Issue(7)：820-824,5.DOI:10.7661/j.cjim.20260426.118
龙牡润燥方治疗血虚风燥型特应性皮炎随机对照研究
Longmu Runzao Formula for Atopic Dermatitis Patients with Blood Deficiency Induced Wind-Dryness Pattern:A Randomized Controlled Trial
摘要
Abstract
Objective To observe the clinical efficacy and safety of Longmu Runzao Formula in treating atopic dermatitis(AD)patients with blood deficiency induced wind-dryness pattern.Methods Totally 123 AD patients with blood deficiency induced wind-dryness pattern who visited the Dermatology Outpatient Department of Xiyuan Hospital,China Academy of Chinese Medical Sciences between December 2022 and December 2023,and 60 met inclusion criteria were enrolled.They were randomly assigned to the treatment group and control group in 1∶1 ratio,with 30 patients in each group.Both groups received topical emollients.Patients in the treatment group took Longmu Runzao Formula,while those in the control group took Loratadine Tablet.Both groups underwent an 8-week treatment cycle,followed by a 4-week follow-up.The following parameters were observed and recorded:pre-and post-treatment scores for the Standardized Scoring of Atopic Dermatitis(SCORAD),Dermatology Life Quality Index(DLQI),Numerical Rating Scale for Itch(NRS),Chinese medicine syndrome scores,scores for primary and secondary symptoms,and adverse reaction.Results Two patients dropped out of the control group during the study.Fifty-eight patients were ultimately included in the analysis(treatment group:30;control group:28).After 8 weeks of treatment,the overall response rate in the treatment group was 86.67％(26/30),significantly higher than that in the control group[60.71％(17/28),x2=5.088,P=0.024].Both groups showed significant reductions in SCORAD,DLQI,NRS,and TCM syndrome scores,as compared with the baseline(P＜0.01).Besides,the improvement in the treatment group was more significant(P＜0.01,P＜0.05).At 4-week follow-up,the above-mentioned indices were better in the treatment group than in the control group(P＜0.05).No significant adverse reactions were observed in either group.Conclusion Longmu Runzao Formula was effective in improving clinical symptoms,alleviating pruritus,and enhancing quality of life in AD patients with blood deficiency induced wind-dryness pattern.(International Traditional Medicine Clinical Trials Registry,No.ITMCTR2025001537)关键词
特应性皮炎/龙牡润燥方/血虚风燥型/随机对照试验Key words
atopic dermatitis/Longmu Runzao Formula/blood deficiency induced wind-dryness pattern/randomized controlled trial引用本文复制引用
崔晗,张天博,迟慧彦,马婉婷,夏慧杰,宋艳丽..龙牡润燥方治疗血虚风燥型特应性皮炎随机对照研究[J].中国中西医结合杂志,2026,46(7):820-824,5.基金项目
中国中医科学院科技创新工程(No.CI2021A02310) （No.CI2021A02310）
