中国妇幼健康研究2026，Vol.37Issue(8)：48-53,6.DOI:10.3969/j.issn.1673-5293.2026.08.007
儿童紫癜性肾炎ET-1、sVCAM-1及sIL-2R水平与病情严重程度和预后的相关性研究
Correlation of ET-1,sVCAM-1,and sIL-2R levels with disease severity and prognosis in children with Henoch-Schonlein purpura nephritis
摘要
Abstract
Objective To analyze the correlation between the levels of endothelin-1(ET-1),soluble vascular cell adhesion molecule-1(sVCAM-1)and soluble interleukin-2 receptor(sIL-2R)and the severity and prognosis of Henoch-Schonlein purpura nephritis(HSPN)in children.Methods A total of 148 children with HSPN(HSPN group)were enrolled in the study.According to the severity,children with HSPN were divided into mild group,moderate group,and severe group.Six months later,they were divided into complete remission group and persistent abnormality group according to the prognosis.Children in the persistent abnormality group were divided into two subgroups,namely mild abnormality group and severe abnormality group.The levels of ET-1,sVCAM-1 and sIL-2R were compared between groups.The correlation between ET-1,sVCAM-1,sIL-2R and the severity of HSPN,and their predictive value for persistent abnormality were analyzed.Results The levels of ET-1,sVCAM-1 and sIL-2R in the severe group,the moderate group,and the mild group decreased in order(F=31.569,22.446 and 15.089,respectively,P<0.001).ET-1,sVCAM-1,and sIL-2R were positively correlated with the severity of HSPN(rs=0.498,0.465 and 0.602,respectively,P<0.001).The levels of ET-1,sVCAM-1 and sIL-2R were significantly lower in the complete remission group than in the mild abnormality group and the severe abnormality group,and significantly lower in the mild abnormality group than in the severe abnormality group(F=20.268,10.760 and 21.722,respectively,P<0.001).The areas under the curve(AUCs)of ET-1,sVCAM-1,sIL-2R,and their combination for predicting persistent abnormality were 0.740(95%CI:0.651-0.829),0.753(95%CI:0.664-0.842),0.729(95%CI:0.637-0.820),0.914(95%CI:0.863-0.964),respectively.The sensitivity and specificity of joint prediction were 89.40%and 88.12%,respectively.Conclusion ET-1,sVCAM-1,and sIL-2R are closely related to the severity of HSPN in children,and their combination demonstrates high efficacy for predicting persistent abnormality in children with HSPN.关键词
儿童/过敏性紫癜/紫癜性肾炎/内皮素1/可溶性血管细胞黏附分子1/可溶性白介素2受体/预后Key words
child/Henoch-Schonlein purpura/Henoch-Schonlein purpura nephritis/Endothelin-1/soluble vascular cell adhesion molecule-1/soluble interleukin-2 receptor/prognosis分类
医药卫生引用本文复制引用
周笑,吴绿仙,姜小云..儿童紫癜性肾炎ET-1、sVCAM-1及sIL-2R水平与病情严重程度和预后的相关性研究[J].中国妇幼健康研究,2026,37(8):48-53,6.基金项目
金华市科技局重点项目(2022-3-130) （2022-3-130）
