河北中医2026，Vol.48Issue(8)：1253-1257,5.DOI:10.3969/j.issn.1002-2619.2026.08.004
连花清瘟颗粒对流感病毒肺炎患儿血清炎症因子及免疫功能的影响
Effects of Lianhua Qingwen granules on serum inflammatory factors and immune function in children with influenza virus pneumonia
摘要
Abstract
Objective To observe the clinical efficacy of Lianhua Qingwen granules in children with influenza virus pneumonia and to evaluate its effects on serum inflammatory factors and immune function.Methods A total of 60 children with influenza virus pneumonia admitted to the Department of Pediatrics of the No.4 People's Hospital of Hengshui from May 2024 to April 2025 were enrolled and randomly assigned,using a random number table,to a control group and a treatment group,with 30 cases in each group.The control group received conventional treatment,while the treatment group received Lianhua Qingwen granules in addition to conventional treatment.Both groups were treated for 7 d.Clinical efficacy,time to symptom relief,serum inflammatory markers(interleukin-6[IL-6],serum amyloid A[SAA],and high-sensitivity C-reactive protein[hs-CRP]),fractional exhaled nitric oxide(FeNO),and T-lymphocyte subsets CD3+,CD4+,CD8+,and CD4+/CD8+were compared between the two groups.Results The treatment group had a significantly higher total effective rate than the control group(93.33%[28/30]vs 80.00%[24/30],P<0.05).The treatment group showed shorter times to normalization of body temperature,relief of cough and sputum production,relief of runny nose,relief of shortness of breath,and disappearance of lung rales than the control group(P<0.05).After treatment,FeNO levels decreased significantly in both groups(P<0.05),and the treatment group had lower FeNO levels than the control group(P<0.05).After treatment,IL-6,SAA,and hs-CRP levels were lower than baseline in both groups(P<0.05),and were lower in the treatment group than in the control group(P<0.05).After treatment,CD4+/CD8+,CD4+,and CD3+levels increased in both groups(P<0.05),whereas CD8+levels decreased(P<0.05).In addition,the treatment group had higher CD4+/CD8+,CD4+,and CD3+levels than the control group(P<0.05),and lower CD8+levels than the control group(P<0.05).Conclusion Lianhua Qingwen granules can effectively improve serum inflammatory factor levels and immune function in children with influenza virus pneumonia,thereby alleviating clinical symptoms and promoting recovery.关键词
肺炎,病毒性/流感病毒/患儿/连花清瘟颗粒/炎症因子/免疫功能Key words
Lianhua Qingwen granules/children's influenza/viral pneumonia/clinical efficacy分类
医药卫生引用本文复制引用
陈云,叶盛前,马耐东,随丽园,张俊娟,沈凤梅,张景丽..连花清瘟颗粒对流感病毒肺炎患儿血清炎症因子及免疫功能的影响[J].河北中医,2026,48(8):1253-1257,5.基金项目
衡水市科学技术局科技计划(自筹经费)项目(编号:2024014049Z) （自筹经费）
