河北中医2026，Vol.48Issue(8)：1258-1262,1267,6.DOI:10.3969/j.issn.1002-2619.2026.08.005
疏风散寒方治疗慢性阻塞性肺疾病急性加重期疗效及相关机制探讨
Preliminary study on the efficacy and related mechanisms of Shufeng Sanhan Formula in the treatment of acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To observe the therapeutic effect of Shufeng Sanhan Formula in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and to preliminarily explore its mechanism of action.Methods A total of 96 patients with AECOPD were randomly assigned,using the random number table method,to two groups,with 48 cases in each group.The control group received standardized Western medical treatment,while the observation group received oral Shufeng Sanhan Formula in addition to the treatment given to the control group.Both groups were treated for 10 days.Before and after treatment,the two groups were compared in terms of traditional Chinese medicine syndrome scores,forced expiratory volume in 1 second(FEV1),FEV1 as a percentage of predicted value(FEV1%),FEV1/forced vital capacity(FVC),arterial partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),blood oxygen saturation(SaO2),and serum levels of zinc finger protein 36(ZFP36)and found in inflammatory zone 2(FIZZ2).Clinical efficacy was also assessed.Results The clinical efficacy of the observation group was superior to that of the control group(P<0.05).After treatment,all traditional Chinese medicine syndrome scores decreased in both groups compared with before treatment(P<0.05),and the scores for cough,sputum production,wheezing,and nasal congestion in the observation group were lower than those in the control group(P<0.05).After treatment,FEV1,FEV1%,and FEV1/FVC increased in both groups compared with before treatment(P<0.05),and the post-treatment values in the observation group were higher than those in the control group(P<0.05).After treatment,PaO2 and SaO2 increased in both groups,whereas PaCO2 decreased(P<0.05);compared with the control group,the observation group had higher PaO2 and SaO2 and lower PaCO2 after treatment(P<0.05).After treatment,serum ZFP36 levels increased in both groups(P<0.05),while FIZZ2 levels decreased(P<0.05);compared with the control group,the observation group had higher serum ZFP36 levels and lower FIZZ2 levels after treatment(P<0.05).Conclusion Shufeng Sanhan Formula can effectively relieve symptoms in patients with AECOPD of the wind-cold invading the lung type,improve lung function and blood gas parameters,and enhance clinical efficacy.Its mechanism may be related to the regulation of ZFP36 and FIZZ2 expression.关键词
慢性阻塞性肺疾病急性加重/中药疗法Key words
Acute exacerbation of chronic obstructive pulmonary disease/Traditional Chinese medicine therapy分类
医药卫生引用本文复制引用
沈珊,吴安源,朱希成,庄玲伶..疏风散寒方治疗慢性阻塞性肺疾病急性加重期疗效及相关机制探讨[J].河北中医,2026,48(8):1258-1262,1267,6.基金项目
国家中医药管理局2022年中医药古籍文献和特色技术传承专项项目(编号:GZY-KJS-2022-030) （编号:GZY-KJS-2022-030）
