黑龙江八一农垦大学学报2026，Vol.38Issue(4)：32-39,112,9.DOI:10.3969/j.issn.1002-2090.2026.04.005
非致细胞病变型牛病毒性腹泻病毒感染BALB/c小鼠肠道微生物变化与分析
Changes and Analysis of Gut Microbiota in BALB/c Mice Infected with Non-Cytopathic Bovine Viral Diarrhea Virus
摘要
Abstract
To investigate the effects of non-cytopathic bovine viral diarrhea virus(NCP BVDV)infection on the gut microbiota of BALB/c mice,the mice were divided into a control group and an NCP BVDV infection group.Fecal samples were collected at 7 days post-infection(7 dpi),and gut microbiota were analyzed by 16S rRNA sequencing.The results demonstrated that NCP BVDV infection altered the composition of gut microbiota.The relative abundances of beneficial bacteria such as Saccharimonadaceae and Ruminococcaceae were significantly decreased in the NCP BVDV group.Meanwhile,the abundances of Ruminococcus and Candidatus Saccharimonas were also markedly reduced.Furthermore,short-chain fatty acid-producing bacteria including Faecalibacterium and Lactobacillus intestinalis exhibited significantly lower abundance after NCP BVDV infection.The above findings firstly reveal an association between NCP BVDV infection and gut microbiota.关键词
牛病毒性腹泻病毒/16S rRNA/肠道微生物/BALB/c 小鼠Key words
BVDV/16S rRNA/gut microbiota/BALB/c mice分类
农业科技引用本文复制引用
王宏瑞,李明轩,孙琬婷,张泽财..非致细胞病变型牛病毒性腹泻病毒感染BALB/c小鼠肠道微生物变化与分析[J].黑龙江八一农垦大学学报,2026,38(4):32-39,112,9.基金项目
黑龙江省自然科学基金项目(YQ2023C036) （YQ2023C036）
大学生创新创业训练计划项目(S202210223029). （S202210223029）
