吉林中医药2026，Vol.46Issue(8)：949-954,6.DOI:10.13463/j.cnki.jlzyy.2026.08.001
基于自噬及氧化应激探讨"益肾通络法"的微观机制及在糖尿病肾病中的作用
Discussion on the micro-mechanism of the"kidney-enhancing and collateral-promoting method"based on autophagy and oxidative stress and its effect in the treatment of diabetic kidney disease
摘要
Abstract
The basic pathogenesis of diabetic kidney disease(DKD)is identified as"kidney deficiency and collateral obstruction"in traditional Chinese medicine,based on which the primary method for its treatment features"enhancing the kidney and promoting kidney collaterals",but the underlying microscopic mechanisms of the method still remain unclear.Oxidative stress injury caused by imbalance between pro-oxidant and antioxidant is one of the important pathogeneses of DKD,and autophagy pathway activation is the key to effectively resist oxidative stress injury of renal intrinsic cells.The"kidney-enhancing and collateral-promoting method"can activate the autophagy pathway,and then remove the excessive accumulation of pro-oxidation substances in the intrinsic cells of DKD kidneys,thus restoring the balance of oxidation/antioxidation and resisting the oxidative stress damage of cells.On the basis of previous research,it is proposed that activating the autophagy pathway to counteract oxidative stress damage is the micro-mechanism of the"kidney-enhancing and collateral-promoting method"for treating DKD,and that elucidating its intrinsic mechanism will provide a theoretical basis for the treatment of DKD in traditional Chinese medicine,inheriting the essence and innovating with integrity.关键词
肾虚络阻/益肾通络法/糖尿病肾病/自噬/氧化应激Key words
kidney deficiency and collateral obstruction/kidney-enhancing and collateral-promoting method/diabetic kidney disease/autophagy/oxidative stress分类
医药卫生引用本文复制引用
原梦飞,孙鲁英,刘伟敬,王娅辉..基于自噬及氧化应激探讨"益肾通络法"的微观机制及在糖尿病肾病中的作用[J].吉林中医药,2026,46(8):949-954,6.基金项目
国家自然科学基金项目(82305206) （82305206）
北京中医药大学校级课题(2022-BUCMXJKY-015) （2022-BUCMXJKY-015）
