实用临床医药杂志2026，Vol.30Issue(15)：28-33,6.DOI:10.7619/jcmp.20262284
3D建模指导下手术治疗功能区脑胶质瘤的效果及对肿瘤全切率、并发症发生率的影响
Efficacy of 3D modeling-guided surgery for functional area glioma and its impact on total tumor resection rate and incidence of complications
摘要
Abstract
Objective To observe the efficacy of 3D modeling-guided surgery for functional area glioma and its impact on total tumor resection rate and incidence of complications.Methods A total of 200 patients with functional area glioma who received treatment at Changsha Fourth Hospital and Hunan Provincial People's Hospital from January 2023 to January 2026 were enrolled as study sub-jects and divided into control group and observation group according to the random number table method,with 100 cases in each group.The control group underwent conventional microscope-assisted surgery,while the observation group underwent surgery under the guidance of 3D modeling technology.Surgical-related indicators(operative time,intraoperative blood loss,time to ambulation,and total tumor resectionrate),tumor markers[neuron-specific enolase(NSE),vascular endothelial growth factor(VEGF),and carbohydrate antigen 153(CA153)],inflammatory cytokines[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1 β(IL-1β),and interferon-γ(IFN-γ)],neurologi-cal function,activities of daily living,and complications were compared between the two groups.Results All 200 patients completed the entire intervention and follow-up,without dropout or miss-ing data.After Bonferroni correction,the observation group had shorter operative time,less intraop-erative blood loss,earlier postoperative time to ambulation,and a higher totaltumor resection rate compared with the control group,with statistically significant differences(P＜0.003).At 3 months postoperatively,the observation group showed a lower National Institutes of Health Stroke Scale(NIHSS)score and a higher Activities of Daily Living(ADL)score than the control group,with statistically significant differences(P＜0.003).At 7 days postoperatively,serum levels of NSE,VEGF,and CA153 decreased in both groups compared with preoperative levels,and the levels in the observation group were lower than those in the control group,with statistically significant differ-ences(P＜0.003).After Bonferroni correction,at 7 days postoperatively,serum levels of TNF-α,IL-6,and IL-1β decreased in both groups compared with preoperative levels,while IFN-γ levels in-creased,and the observation group had lower levels of TNF-α,IL-6,and IL-1 β and a higher level of IFN-γ than the control group,with statistically significant differences(P＜0.003).After Bonfer-roni correction,the total incidence of complications within 30 days postoperatively in the observation group was lower than that in the control group,with a statistically significant difference(P＜0.003).Conclusion 3D modeling-guided surgery for functional area glioma can significantly opti-mize surgical-related indicators,improve total tumor resection rate,effectively reduce postoperative complication incidence,alleviate inflammatory responses,and improve neurological function and ac-tivities of daily living,thereby providing a superior strategy for the surgical treatment of functional area glioma.关键词
3D建模/神经胶质瘤/功能区/肿瘤全切率/神经元特异性烯醇化酶/血管内皮生长因子/炎症因子/随机对照试验Key words
3D modeling/glioma/functional area/total tumor resection rate/neuron-specific enolase/vascular endothelial growth factor/inflammatory factors/randomized controlled trial分类
医药卫生引用本文复制引用
文擘彬,王争,甘杰,周文,周定洲..3D建模指导下手术治疗功能区脑胶质瘤的效果及对肿瘤全切率、并发症发生率的影响[J].实用临床医药杂志,2026,30(15):28-33,6.基金项目
湖南省卫生健康委科研项目计划(202204045055) （202204045055）
