实用临床医药杂志2026，Vol.30Issue(15)：54-58,5.DOI:10.7619/jcmp.20262239
肌肉注射鼠神经生长因子、甲钴胺对突发性感音神经性听力损失患者的治疗效果
Therapeutic effects of intramuscular injection of mouse nerve growth factor and mecobalamin in patients with sudden sensorineural hearing loss
摘要
Abstract
Objective To analyze the therapeutic effects of intramuscular injection of mouse nerve growth factor(mNGF)and mecobalamin in patients with sudden sensorineural hearing loss(SSNHL).Methods A total of 303 patients with SSNHL were enrolled and divided into mNGF group(n=175)and mecobalamin group(n=128)according to the treatment modality.Propensity score matching(PSM)was performed at 1∶1 ratio to balance covariates between the mNGF and mecobal-amin groups,thereby reducing confounding bias in baseline data.The McNemar test was used to com-pare the efficacy of hearing improvement between the two groups in paired samples.Results After PSM,105 pairs of patients were successfully matched between the mNGF and mecobalamin groups.No statistically significant differences were observed in baseline data,clinical characteristics,treatment dosage and treatment course between the two groups(P＞0.05).The overall response rates of the two groups were 32.38％and 42.86％,respectively,with no statistically significant difference between the groups(P=0.16,RD=-10.48％,95％CI:-24.61％to 3.65％).Conclusion Intramus-cular injection of mNGF and mecobalamin yields comparable therapeutic effects in the treatment of SSNHL,and both are effective clinical treatment options.关键词
突发性感音神经性听力损失/鼠神经生长因子/甲钴胺/倾向评分匹配/营养神经类药物/肌肉注射/中重度耳聋/McNemar检验Key words
sudden sensorineural hearing loss/mouse nerve growth factor/mecobalamin/pro-pensity score matching/neurotrophic drugs/intramuscular injection/moderate-to-severe hearing loss/McNemar test分类
医药卫生引用本文复制引用
陈海军,李文静,夏樱心,张玲,闪寒寒,尤建强,薛海翔..肌肉注射鼠神经生长因子、甲钴胺对突发性感音神经性听力损失患者的治疗效果[J].实用临床医药杂志,2026,30(15):54-58,5.基金项目
常州市科技局市厅级项目(CJ20245018) （CJ20245018）
常州市卫建委科技项目(QN202403) （QN202403）
