临床肝胆病杂志2026，Vol.42Issue(7)：1493-1500,8.DOI:10.12449/JCH260702
肝细胞癌超声诊疗基础研究进展:从诊断、治疗到诊疗一体化
Advances in basic research on ultrasound diagnosis and treatment of hepatocellular carcinoma:From diagnosis and treatment to integrated management
摘要
Abstract
The precise diagnosis and treatment of hepatocellular carcinoma(HCC)face major challenges such as the complexity of tumor microenvironment,treatment resistance,and a high risk of recurrence and metastasis.In recent years,ultrasound technology has moved beyond its traditional role in screening and localization,gradually evolving into a multidimensional therapeutic platform capable of energy activation,targeted delivery,local ablation,immune modulation,and therapeutic feedback.This article systematically reviews the latest advances in the basic research on ultrasound techniques in HCC treatment and integrated management.In terms of treatment,intervention strategies represented by microbubble/nanobubble-mediated delivery,sonodynamic therapy,high-intensity focused ultrasound,and histotripsy not only enable in situ physical destruction of lesions,but also effectively reverse tumor immune tolerance networks through deep synergy with sonogenetics,metabolic reprogramming,and immunochemotherapy.In terms of integrated management,novel sonosensitive nanodelivery systems provide a platform for energy activation and targeted controlled release.To address the translational bottlenecks in this field,it is recommended to develop standardized consensus on preclinical therapeutic ultrasound parameters,in order to establish a new translational paradigm for individualized precise diagnosis and treatment of HCC.关键词
癌,肝细胞/超声检查/分子成像/声动力疗法/体外冲击波疗法/诊断/治疗学Key words
Carcinoma,Hepatocellular/Ultrasonography/Molecular Imaging/Sonodynamic Therapy/Extracorporeal Shockwave Therapy/Diagnosis/Therapeutics引用本文复制引用
汪思睿,顾卫琪,沈玉婷,尹豪豪,徐辉雄..肝细胞癌超声诊疗基础研究进展:从诊断、治疗到诊疗一体化[J].临床肝胆病杂志,2026,42(7):1493-1500,8.基金项目
国家自然科学基金(82302206,82430064) （82302206,82430064）
国家重点研发计划(2023YFC2414204,2023YFC2414203,2023YFC2414202) （2023YFC2414204,2023YFC2414203,2023YFC2414202）
复旦大学附属中山医院科研发展基金(2022ZSQD07) （2022ZSQD07）
上海市扬帆计划(23YF1441600) （23YF1441600）
中国博士后科学基金(2023TQ0073) National Natural Science Foundation of China(82302206,82430064) （2023TQ0073）
National Key R&D Program of China(2023YFC2414204,2023YFC2414203,2023YFC2414202) （2023YFC2414204,2023YFC2414203,2023YFC2414202）
Scientific Development Fund of Zhongshan Hospital,Fudan University(2022ZSQD07) （2022ZSQD07）
Shanghai Sailing Program(23YF1441600) （23YF1441600）
China Postdoctoral Science Foundation(2023TQ0073) （2023TQ0073）
