临床肝胆病杂志2026，Vol.42Issue(7)：1526-1531,6.DOI:10.12449/JCH260707
肝细胞癌超声造影研究热点与进展
Research hotspots and advances in contrast-enhanced ultrasound for hepatocellular carcinoma
摘要
Abstract
Hepatocellular carcinoma(HCC)is the most common type of primary liver cancer and has a poor overall prognosis.Contrast-enhanced ultrasound(CEUS)plays a crucial role in the diagnosis,treatment response evaluation,and prognostic evaluation of HCC.This article systematically reviews the literature characteristics,research hotspots,and frontier advances of CEUS in the field of HCC.There has been a gradual increase in annual publication volume in this field,with China ranking first globally in the total number of publications.Highly cited articles mainly focus on clinical guidelines and standardized protocols.Keyword analysis shows that the main research hotspots in this field include the diagnosis and standardized assessment of HCC,differential diagnosis,treatment response evaluation after local therapy,and prognostic prediction.Meanwhile,microvascular invasion,artificial intelligence(AI),and super-resolution ultrasound(SRUS)may be emerging as cutting-edge frontiers in this field.Specifically,AI can be used for the auxiliary diagnosis of HCC,the evaluation of tumor biological characteristics,and prognostic prediction,and SRUS can overcome the acoustic diffraction limit to achieve precise microvascular imaging of the liver.Currently,a solid foundation has been established for the research on CEUS in HCC,showing a strong orientation toward clinical practice.In the future,emerging technologies such as CEUS-based AI models and SRUS are expected to further promote the development of precise diagnosis and treatment for HCC.关键词
癌,肝细胞/超声造影/文献计量学/人工智能/超分辨超声Key words
Carcinoma,Hepatocellular/Contrast Enhanced Ultrasound/Bibliometrics/Artificial Intelligence/Super Resolution Ultrasound引用本文复制引用
侯雯菲,汤珈嘉,杨萌..肝细胞癌超声造影研究热点与进展[J].临床肝胆病杂志,2026,42(7):1526-1531,6.基金项目
国家自然科学基金青年科学基金项目(62325112) （62325112）
国家自然科学基金联合基金项目(U22A2023) （U22A2023）
中国医学科学院医学与健康科技创新工程项目(2025-I2M-XHJC-003) （2025-I2M-XHJC-003）
中央级公益性科研院所基本科研业务费项目(2024-RC320-02) National Natural Science Foundation of China(62325112) （2024-RC320-02）
National Natural Science Foundation of China(U22A2023) （U22A2023）
CAMS Innovation Fund for Medical Sciences(2025-I2M-XHJC-003) （2025-I2M-XHJC-003）
Fundamental Research Funds for the Central Public-interest Scientific Institution of Chinese Academy of Medical Sciences(2024-RC320-02) （2024-RC320-02）
