临床肝胆病杂志2026，Vol.42Issue(7)：1532-1540,9.DOI:10.12449/JCH260708
慢性乙型肝炎功能性治愈的多维度诊断标志物
Multidimensional diagnostic biomarkers for functional cure of chronic hepatitis B
摘要
Abstract
Chronic hepatitis B(CHB)is a significant public health issue worldwide.The persistent presence of covalently closed circular DNA of the hepatitis B virus(HBV)and the integration of the viral genome are the main obstacles limiting the achievement of virological cure in CHB.Functional cure has now become an important goal in antiviral therapy for CHB,and its accurate determination and efficacy prediction rely on a comprehensive assessment of multidimensional diagnostic markers.This article systematically reviews the research advances in diagnostic markers associated with functional cure in CHB,focusing on the clinical value of serological and virological indicators(HBsAg quantification and HBV DNA),genomic,transcriptomic,proteomic,and metabolomic markers,and indicators associated with host innate immunity and adaptive immunity.Furthermore,it discusses future research directions such as the establishment of unified detection standards and the construction of predictive models combining multiple markers,in order to promote the precise assessment and individualized management of functional cure in CHB.关键词
乙型肝炎,慢性/功能性治愈/生物标记Key words
Hepatitis B,Chronic/Functional Cure/Biomarkers引用本文复制引用
孙鹤鸣,孔菲,王星语,牛俊奇,高沿航..慢性乙型肝炎功能性治愈的多维度诊断标志物[J].临床肝胆病杂志,2026,42(7):1532-1540,9.基金项目
国家科技重大专项(2025ZD01905902) （2025ZD01905902）
国家重点研发计划(2024YFE0213800) National Science and Technology Major Project of China(2025ZD01905902) （2024YFE0213800）
National Key Research and Development Program of China(2024YFE0213800) （2024YFE0213800）
