临床神经外科杂志2026，Vol.23Issue(4)：367-372,6.DOI:10.3969/j.issn.1672-7770.2026.04.002
螺旋CT联合血清PDCD4、LTBP-2 对脑梗死患者颈动脉斑块稳定性的评估价值
Spiral CT combined with serum PDCD4 and LTBP-2 for evaluating carotid plaque stability in patients with cerebral infarction
摘要
Abstract
Objective Based on carotid artery ultrasound imaging,the differences among spiral CT features and serum levels of programmed cell death factor 4(PDCD4)and latent transforming growth factor beta binding protein-2(LTBP-2)were compared between the stable and vulnerable plaque groups,and to explore the correlation of these indicators with carotid plaque stability(CPS)in patients with cerebral infarction(CI)and their combined predictive value.Methods A total of 164 CI patients admitted to Fengfeng General Hospital,North China Medical and Health Group from March 2022 to November 2024 were selected.According to the imaging reference standard,they were divided into stable plaque group(n=93)and vulnerable plaque group(n=71).Receiver operating characteristic(ROC)curve was used to evaluate the efficacy of spiral CT combined with serum PDCD4 and LTBP-2 in predicting CPS in CI patients.The Kappa test was used to analyze the consistency between the combination of the three and the imaging reference standard.Results The sensitivity and specificity of spiral CT evaluation were 77.46%and 76.34%,respectively.The levels of PDCD4 and LTBP-2 in the vulnerable plaque group were higher than those in the stable plaque group,and the differences were statistically significant(P<0.05).The areas under the curve(AUC)of serum PDCD4,LTBP-2 alone and their combination for evaluating CPS in CI patients were 0.713,0.803 and 0.924,respectively.The sensitivity and specificity of spiral CT combined with serum PDCD4 and LTBP-2 for evaluating CPS in CI patients were 92.96%and 83.87%,respectively,and the consistency with the imaging reference standard was high(Kappa value=0.756,P<0.001).Conclusions The value of spiral CT combined with serum PDCD4 and LTBP-2 in evaluating CPS in CI patients has a high consistency with carotid artery ultrasound.关键词
脑梗死/颈动脉斑块稳定性/螺旋CT/程序性细胞死亡因子4/潜伏转化生长因子β结合蛋白-2Key words
cerebral infarction/carotid plaque stability/spiral CT/programmed cell death factor 4/latent transforming growth factor beta binding protein-2分类
医药卫生引用本文复制引用
王超,王雪皎,于欣欣,申真,赵姗姗..螺旋CT联合血清PDCD4、LTBP-2 对脑梗死患者颈动脉斑块稳定性的评估价值[J].临床神经外科杂志,2026,23(4):367-372,6.基金项目
邯郸市科学技术研究与发展计划项目(23422083383) （23422083383）
