临床神经外科杂志2026，Vol.23Issue(4)：412-417,6.DOI:10.3969/j.issn.1672-7770.2026.04.009
免疫炎症指标CAR联合NLR在自发性基底节区出血保守治疗患者短期预后中的应用研究
Application of immune inflammatory markers CAR combined with NLR in short-term prognosis of conservative treatment for patients with spontaneous basal ganglia hemorrhage
摘要
Abstract
Objective To evaluate the predictive value of the C-reactive protein-to-albumin ratio(CAR)combined with the neutrophil-to-lymphocyte ratio(NLR)for short-term prognosis in patients with conservatively treated spontaneous basal ganglia hemorrhage.Methods The clinical data of 137 spontaneous basal ganglia hemorrhage patients conservatively treated in The Affiliated Chuzhou Hospital of Anhui Medical University from January 2022 to June 2025 were retrospectively analyzed.Patients were divided into a good prognosis group(n=73,mRS≤3)and a poor prognosis group(n=64,3<mRS<6)according to the 3-month modified Rankin scale(mRS)score.Binary Logistic regression was used to identify factors independently associated with poor short-term prognosis,and receiver operating characteristic(ROC)curve analysis was performed to assess the predictive efficacy of CAR,NLR,and their combination.Results The CAR[(2.60±0.83)vs.(1.99±0.80)]and NLR[(5.46±2.18)vs.(3.69±1.76)]levels in the poor prognosis group were significantly higher than those in the good prognosis group(both P<0.001).Multivariate Logistic regression analysis showed that the Glasgow coma scale(GCS)score(P=0.009),CAR(P<0.001),and NLR(P<0.001)were independently associated with poor short-term prognosis.ROC curve analysis showed that the area under the curve(AUC)of CAR and NLR was 0.70 and 0.74,respectively,with optimal cut-off values of 2.71 and 4.91,respectively.The AUC of the combined CAR and NLR was 0.81,which was significantly higher than that of CAR alone(Z=3.10,P=0.002)and NLR alone(Z=1.99,P=0.047).Conclusions Both CAR and NLR have predictive value for short-term prognosis in patients with conservatively managed spontaneous basal ganglia hemorrhage,and their combination shows better predictive performance.关键词
CAR/NLR/自发性基底节区出血/保守治疗/短期预后Key words
CAR/NLR/spontaneous basal ganglia hemorrhage/conservative treatment/short-term prognosis分类
医药卫生引用本文复制引用
石碑田,李心伟,王建东,张超,侯仕强..免疫炎症指标CAR联合NLR在自发性基底节区出血保守治疗患者短期预后中的应用研究[J].临床神经外科杂志,2026,23(4):412-417,6.基金项目
安徽省高等学校科学研究重点项目(2022AH050769) （2022AH050769）
