摘要
Abstract
To address the problems of equipment complexity and the high operational and maintenance demands of current vacuum boiling evaporation concentration devices for pharmaceutical liquids,the research group designed a heat pump assisted surface evaporation concentration device for pharmaceutical liquids.This device utilized a heat pump for heating and concentrated the pharmaceutical liquid through a custom-designed polyhedral hollow ball evaporation unit.It featured simplified equipment,enabled atmospheric-pressure low-temperature concentration,and ease of operation and maintenance.An experimental device using Shuanghuanglian oral liquid(as-received)as the working fluid was established to investigate the variation of performance indicators such as concentration rate and specific moisture evaporation ratio(RSMER)with pharmaceutical liquid temperature,pharmaceutical liquid flow rate,and sweeping gas flow rate.The results show that,within the permissible operating ranges of the device,increasing pharmaceutical liquids temperature,pharmaceutical liquids flow rate,and sweeping gas flow rate is all conducive to enhancing the concentration rate,RSMER,and volumetric evaporation flux,while the thermal efficiency of the evaporation process remains relatively stable,fluctuating within the range of 86.0%to 91.0%.The characteristic equations of the device for heat pump assisted surface evaporation concentration of pharmaceutical liquids are constructed based on the experimental data.These equations can serve as a reference for the optimization and control of the concentration device,and a set of preferred operating parameters for the experimental setup is obtained:the sweeping gas flow rate is 165.85 g/s,the pharmaceutical liquids flow rate is 69.19 g/s,the pharmaceutical liquid temperature is 46.95℃,and the concentration rate is 2.22 kg/h.Under these conditions,the RSMER is 5.89 kg/(kW·h),which is 24.79%higher than that before the device is commissioned.关键词
药液浓缩/表面蒸发浓缩/热泵/多面空心球/常压浓缩/低温浓缩Key words
concentration of pharmaceutical liquids/surface evaporation concentration/heat pump/polyhedral hollow ball/atmospheric pressure concentration/low-temperature concentration分类
机械制造
