日用化学品科学2026，Vol.49Issue(8)：60-69,10.DOI:10.3969/j.issn.1006-7264.2026.08.009
化学刺激物诱导炎症后色素沉着的皮肤生理参数变化探究
Exploration of skin physiological parameter changes in post-inflammatory hyperpigmentation induced by chemical irritants
林雅慧 1赵钰 1汪文彦 1赵玥 1赵晓 1谢阿贵1
作者信息
- 1. 片仔癀(上海)生物科技研发有限公司,上海 200030
- 折叠
摘要
Abstract
The changes in skin physiological parameters associated with post-inflammatory hyperpigmentation induced by chemical irritants using a patch test model was discussed.Thirty-two Chinese female subjects with dorsal skin ITA° values ranging from 28° to 50° were enrolled.Skin irritation was induced by applying chemical irritants under occlusive patches,and non-invasive instruments were used to monitor skin color,barrier function,and surface morphology parameters.Statistical methods were applied for evaluations.The results showed that melanin index(MI)values decreased initially(D0～D1)and increased later(D4～D7),while erythema index(EI)values exhibited the opposite trend,which reflect a dynamic transition from erythema to hyperpigmentation.In addition,chemical irritation resulted in higher TEWL,EI,a*,and skin smoothness values,along with lower L*,ITA°,and stratum corneum water content,manifested as darker skin tone,reduced brightness,dry and flaky skin,and rough texture.关键词
炎症后色素沉着/斑贴造模/化学刺激/皮肤肤色Key words
post-inflammatory hyperpigmentation/patch test/chemical irritation/skin color分类
化学化工引用本文复制引用
林雅慧,赵钰,汪文彦,赵玥,赵晓,谢阿贵..化学刺激物诱导炎症后色素沉着的皮肤生理参数变化探究[J].日用化学品科学,2026,49(8):60-69,10.
