肿瘤预防与治疗2026，Vol.39Issue(8)：625-636,12.DOI:10.3969/j.issn.1674-0904.2026.08.002
食管癌手术患者临床特征及预后分析——2019年四川省肿瘤医院年度报告
Clinical Characteristics and Prognosis Analysis of Surgically Treated Esophageal Cancer Patients:An Annual Institutional Report from Sichuan Cancer Hospital,2019
摘要
Abstract
Objective:Esophageal cancer(EC)remains a surgically oriented multimodal disease.Real-world data from high-volume EC treatment centers provide valuable guidance for clinical practice.This article describes the clinical character-istics,perioperative treatment status,and long-term survival outcomes of EC patients admitted to Sichuan Cancer Hospital in 2019.Methods:Clinical data were obtained from the prospective single-disease esophageal cancer database at Sichuan Cancer Hospital.We described the pathological characteristics,perioperative treatment modalities,and long-term survival outcomes of the patients included in this study.Results:A total of 325 EC patients were included,of whom 266(81.85%)were male.Most tumors were in the middle thoracic esophagus(56.00%)and were predominantly squamous cell carcinoma(92.92%).Neoadjuvant therapy was administered to 107 patients(32.92%)prior to surgery.The McKeown esophagecto-my was the most performed surgical procedure(91.08%).The 30-day postoperative mortality rate was 1.20%,and the R0 resection rate was 99.70%.The most common stage was pT3/ypT3.Postoperative complications were observed in 25.85%of patients.The 1-,3-,and 5-year overall survival(OS)rates were 85%,67%,and 63%,respectively.A 1:1 propensity score-matched analysis,accounting for baseline characteristics and pathological staging,showed that patients who received neoadjuvant therapy had significantly improved survival compared to those undergoing surgery alone(median OS:not reached vs 25 months;5-year OS rates:50.90%vs 29.70%;P=0.046).Conclusion:Patients undergoing esophagectomy via right thoracic approach with standardized lymph node dissection achieving R0 resection can achieve satisfactory long-term sur-vival outcomes.Patients with locally advanced resectable esophageal cancer treated with neoadjuvant therapy preoperatively can achieve improved long-term survival outcomes.关键词
食管癌/食管切除术/年度报告/新辅助治疗/总生存率Key words
Esophageal cancer/Esophagectomy/Annual institutional data/Neoadjuvant therapy/Overall survival rate分类
医药卫生引用本文复制引用
熊继承,青浩渺,韩泳涛,冷雪峰,谢钦,缪艳,彭林,方强,肖文光,吕家华,陈永昌,周也涵..食管癌手术患者临床特征及预后分析——2019年四川省肿瘤医院年度报告[J].肿瘤预防与治疗,2026,39(8):625-636,12.基金项目
国家自然科学基金面上项目(编号:82472663) （编号:82472663）
四川省国际科技创新合作项目(编号:2024YFHZ0322) （编号:2024YFHZ0322）
四川省科技厅重点研发项目(编号:2023YFS0044) （编号:2023YFS0044）
成都市科技局重点研发项目(编号:2024-YF05-00797-SN) （编号:2024-YF05-00797-SN）
吴阶平医学基金会临床科研专项资助基金(编号:320.6750.2023-05-141) （编号:320.6750.2023-05-141）
四川省临床重点专科建设项目 This study was supported by National Natural Science Foundation of China(No.82472663),and by grants from Science and Technology Department of Sichuan Province(No.2024YFHZ0322,No.2023YFS0044),Chengdu Science and Technology Bureau(No.2024-YF05-00797-SN),Wu Jieping Medical Foundation(No.320.6750.2023-05-141)and Health Commision of Sichuan Province. （No.82472663）
