时珍国医国药2026，Vol.37Issue(16)：3054-3061,8.DOI:10.70976/j.1008-0805.SZGYGY-2026-1608
地黄烘制及质量评价研究
Study on drying and quality evaluation of Radix Rehmanniae
摘要
Abstract
Objective To investigate the effects of different drying times on the quality of Radix Rehmanniae and to provide a theoreti-cal basis for refined processing and quality standard research.Methods The morphological changes of Radix Rehmanniae under differ-ent drying times were observed.High-performance liquid chromatography(HPLC)was used to determine the contents of catalpol,rehm-annioside D,leonuride,and verbascoside.Fourier transform infrared(FT-IR)spectroscopy was employed to analyze the differences in infrared spectra.Results With the prolongation of drying time,the appearance of Radix Rehmanniae changed from light red-yellow to dark brown-yellow,the texture changed from soft to hard,and the"chrysanthemum-like pattern"gradually shrank with deepened color(from yellowish-white to brownish-black).The contents of catalpol,rehmannioside D,and leonuride showed fluctuating changes,while the content of verbascoside decreased first and then increased.Principal component analysis(PCA)suggested that the suitable drying time was 80-88 h or 96-100 h.Additionally,FT-IR spectra revealed differences in the characteristic peaks of Radix Rehmanniae under different drying times.Cluster analysis and PCA indicated that the suitable drying time ranged from 44 to 100 h.Conclusion Drying for 80-100 h can contribute to the quality enhancement of Radix Rehmanniae.This study provides a scientific basis for the refined drying and quality evaluation of Radix Rehmanniae,and offers theoretical references for ensuring the stability and controllability of quality of Chinese medicinals(CMs).关键词
地黄/烘制/高效液相/红外光谱/主成分分析/聚类分析Key words
Radix Rehmanniae/Drying/High-performance liquid chromatography/Infrared spectroscopy/Principal compo-nent analysis/Cluster analysis分类
医药卫生引用本文复制引用
姜延光,顾旭鹏,董宁,杨林林,李汉伟,董诚明..地黄烘制及质量评价研究[J].时珍国医国药,2026,37(16):3054-3061,8.基金项目
国家自然科学基金(32401226) （32401226）
河南省重点研发专项(251111310500,231111312700) （251111310500,231111312700）
