同位素2026，Vol.39Issue(4)：307-314,8.DOI:10.7538/tws.2026.youxian.041
TDCR切伦科夫计数法测量223Ra的活度
Determination of 223Ra Activity by TDCR Cherenkov Counting Technique
王路生 1宋丽娟 2何欢 3戴雄新1
作者信息
- 1. 中国原子能科学研究院,北京 102413||中国科学院高能物理研究所,北京 100049||散裂中子源科学中心,广东 东莞 523803
- 2. 中国科学院高能物理研究所,北京 100049||散裂中子源科学中心,广东 东莞 523803
- 3. 中国原子能科学研究院,北京 102413
- 折叠
摘要
Abstract
To address the requirement for accurate activity measurement of the medical α-emitting radionuclide 223Ra in radiopharmaceutical development and clinical application,this study established a triple-to-double coincidence ratio(TDCR)Cherenkov counting method for measuring 223Ra activity.In this work,a TDCR liquid scintillation counter was used to calibrate the activity of 223Ra.The Cherenkov spectra of 223Ra and the TDCR efficiency correction curve was obtained.The Cherenkov spectra,detection efficiencies,and the effects of color quenching between 223Ra and 224Ra were compared.The results showed that Cherenkov light originating from the daughter nuclides 211Pb and 207Tl can be used for accurate activity determination of 223Ra,with a maximum detection efficiency of up to 60%and a minimum detectable activity of 0.2 Bq.A good correlation was observed between TDCR values and the detection efficiency of 223Ra,enabling efficiency correction in activity measurements.The TDCR Cherenkov counting method exhibited similar detection efficiencies for 223Ra and 224Ra,whereas color quenching affected 223Ra more significantly.This study demonstrated that TDCR Cherenkov counting offers a sensitive,accurate,and rapid approach for determining the activity of 223Ra,supporting radiopharmaceutical development and clinical applications.关键词
223Ra/三管-两管符合比(TDCR)/切伦科夫计数/液体闪烁计数Key words
223Ra/triple-to-double coincidence ratio(TDCR)/Cherenkov counting/liquid scintillation counting分类
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王路生,宋丽娟,何欢,戴雄新..TDCR切伦科夫计数法测量223Ra的活度[J].同位素,2026,39(4):307-314,8.
