新医学2026，Vol.57Issue(8)：825-835,11.DOI:10.12464/j.issn.0253-9802.2026-0754
癌胚抗原电化学免疫传感中功能纳米材料的设计策略与临床转化研究进展
Research progress on design strategies and clinical translation of functional nanomaterials in electrochemical immunosensing for carcinoembryonic antigen
摘要
Abstract
Compared with conventional clinical testing techniques,electrochemical detection of tumor markers offers distinct advantages in accuracy,rapid response,and real-time monitoring,providing early warning for related diseases.The performance of electrochemical immunosensors is governed by multiple factors,among which the selection of nanomaterials is particularly critical.This review focuses on carcinoembryonic antigen(CEA)as the target analyte and addresses the general principles of electrochemical immunosensor design and fabrication.Based on a bibliometric visualization analysis,research hotspots and evolutionary trends are revealed,and electrochemical detection principles of linear sweep voltammetry,cyclic voltammetry,and square wave voltammetry are described.Three representative nanomaterials—noble metals,transition metal compounds,and carbon-based materials—are systematically analyzed in terms of their structure-activity relationships and applications in immunosensor design.The results indicate that multi-component composites,leveraging synergistic effects among constituents,can effectively integrate conductivity and catalytic activity,representing a key route to overcome the sensitivity bottleneck.Furthermore,the combination of screen-printed electrodes with microfluidic technology facilitates the gradual standardization of sensor fabrication,serving as a pivotal approach to bridge the gap between laboratory research and clinical translation.This technical pathway,characterized by batch electrode fabrication and automated micro-sample processing,can reduce detection costs and operational errors,and is expected to provide useful insights for developing highly sensitive and low-cost point-of-care CEA detection devices.关键词
纳米材料/电化学/免疫传感器/癌胚抗原Key words
Nanomaterials/Electrochemistry/Immunosensors/Carcinoembryonic antigen分类
医药卫生引用本文复制引用
仝文婷,杨笑语,陈子昂,张婷婷,卢文卜,魏明..癌胚抗原电化学免疫传感中功能纳米材料的设计策略与临床转化研究进展[J].新医学,2026,57(8):825-835,11.基金项目
山西省基础研究计划项目(202503021211202) （202503021211202）
江苏高校青蓝工程中青年学术带头人培养对象(苏教师函[2025]16号) （苏教师函[2025]16号）
南京医科大学康达学院"聚贤计划"(KD2024JXJH003) （KD2024JXJH003）
