新医学2026，Vol.57Issue(8)：900-909,10.DOI:10.12464/j.issn.0253-9802.2026-0596
维持性血液透析患者肌少症的发生机制、临床结局及干预策略研究进展
Research progress on the pathogenesis,clinical outcomes,and intervention strategies of sarcopenia in patients undergoing maintenance hemodialysis
摘要
Abstract
Sarcopenia is highly prevalent among patients undergoing maintenance hemodialysis(MHD)and represents an important clinical problem affecting functional status,quality of life,and long-term prognosis.Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and function.In MHD patients,it is often driven by the combined effects of multiple factors such as chronic inflammation,malnutrition,metabolic disorders,endocrine abnormalities,and dialysis-related stress.Its pathogenesis is complex,its progression is relatively rapid,and its clinical impact is substantial.Given the high prevalence of sarcopenia and its adverse clinical outcomes in the MHD population,a systematic understanding of its pathogenesis,clinical outcomes,and intervention strategies is of great significance for the early identification of high-risk patients in clinical practice.This article reviews the definition,epidemiological characteristics,pathogenesis,clinical outcomes,and intervention and management strategies of sarcopenia in MHD patients,with the aim of deepening the understanding of its clinical significance in this population and providing a reference for clinical prevention and treatment as well as future research.关键词
维持性血液透析/肌少症/发生机制/临床结局/干预管理策略Key words
Maintenance hemodialysis/Sarcopenia/Pathogenesis/Clinical outcomes/Intervention and management strategies分类
医药卫生引用本文复制引用
王娇,郭子维,张祖隆..维持性血液透析患者肌少症的发生机制、临床结局及干预策略研究进展[J].新医学,2026,57(8):900-909,10.基金项目
贵州省卫生健康委科学技术基金项目(gzwkj2021-137) （gzwkj2021-137）
