云南民族大学学报（自然科学版）2026，Vol.35Issue(4)：456-463,8.DOI:10.3969/j.issn.1672-8513.2026.04.003
玄参-夏枯草药对治疗桥本甲状腺炎作用机制的研究
Study on mechanisms of drug pair of Scrophularia-Prunella vulgaris on the treatment of Hashimoto's thyroiditis
摘要
Abstract
This study aims to explore the mechanism of Scrophularia ningpoensis-Prunella vulgaris herb pair in the treatment of Hashimoto's thyroiditis by network pharmacology and molecular docking.The active ingredient targets and disease targets of Scrophularia Radix and Prunellae Spica were screened in TCMSP,Uniprot,OMIM and GeneCards databases.The'drug-active ingredient-target'(D-A-T)network diagram was drawn,and the core targets in the network were excavated.GO function enrichment analysis and KEGG pathway enrichment analysis were performed on the core targets.Finally,molecular docking was performed to evaluate the predicted interactions between the core components and core targets.It was found that S.ningpoensis and P.vulgaris acted on AKT1,TNF,CASP3,TP53,VEGFA,IL-6 and other core targets through quercetin,β-sitosterol,kaempferol,luteolin,paeoniflorin and other core components,and regulated IL-17,PI3K-Akt,TNF,HIF-1 and other signaling pathways.The molecular docking results showed that the core components and core targets had good binding activity.In this study,network pharmacology and molecular docking techniques were used to reveal that S.ningpoensis and P.vulgaris regulate HT in a multi-component,multi-target and systematic manner,providing a basis for further research.关键词
玄参/夏枯草/桥本甲状腺炎/网络药理学/作用机制/分子对接Key words
Scrophularia/Prunella vulgaris/Hashimoto's thyroiditis/network pharmacology/mechanism of action/molecular docking分类
医药卫生引用本文复制引用
郅扶旻,孙士博,王岩岩,于洪宇,徐洪涛..玄参-夏枯草药对治疗桥本甲状腺炎作用机制的研究[J].云南民族大学学报（自然科学版）,2026,35(4):456-463,8.基金项目
黑龙江省中医药科研项目(ZHY2022-154) （ZHY2022-154）
黑龙江中医药大学附属第一医院国家自然科学基金培育支持计划项目(PYMS202501013). （PYMS202501013）
