医学信息2026，Vol.39Issue(15)：29-34,6.DOI:10.3969/j.issn.1006-1959.2026.15.004
康艾注射液调控肠道微生物代谢物干预结直肠癌的机制研究
Study on the Mechanism of Kang'ai Injection Intervening Colorectal Cancer by Regulating Intestinal Microbial Metabolites
摘要
Abstract
Objective To explore the potential molecular mechanism of Kang'ai injection against colorectal cancer via regulating intestinal microbial metabolites based on network pharmacology and molecular docking.Methods The active components and targets of Kang'ai injection were obtained from TCMSP and BATMAN-TCM databases.GutMGene database was used to collect the targets related to intestinal microbial metabolites.The targets of colorectal cancer were retrieved based on GeneCards,OMIM,DisGeNET and TTD databases.The intersection of the three types of targets was used to screen potential targets.Cytoscape was used to construct the active component-target network,and the PPI protein interaction network was constructed based on the STRING database and topological analysis was performed.The GO function and KEGG pathway enrichment analysis of the core targets were completed by R software,and the binding stability of the main active components to the key targets was verified by molecular docking.Results Huagiannin,isoflavanone,and kaempferol were identified as the main active ingredients,while IL6,TP53,and AKT1 were determined as the key therapeutic targets.GO enrichment analysis indicated that the biological processes were mainly involved in cell proliferation,apoptosis,and inflammatory response.KEGG pathway enrichment analysis revealed that the core targets were primarily enriched in signaling pathways including AGE-RAGE and IL-17.Molecular docking demonstrated favorable binding affinity between the main active ingredients and the key targets.Conclusion Kang'ai injection exhibits synergistic anti-tumor properties characterized by multi-component,multi-target,and multi-pathway actions.It may exert potential anti-colorectal cancer effects by modulating inflammatory,immune,and metabolism-related signaling pathways,thereby improving the gut microbial microenvironment.However,as this study is solely based on network pharmacology predictions without in vivo or in vitro experimental validation,certain limitations exist.Further experimental studies are warranted to substantiate the underlying mechanisms and provide theoretical support for its adjuvant therapy in colorectal cancer.关键词
康艾注射液/结直肠癌/肠道微生物代谢物/网络药理学/分子对接Key words
Kang'ai injection/Colorectal cancer/Intestinal microbial metabolites/Network pharmacology/Molecular docking分类
医药卫生引用本文复制引用
张馨,田金徽,郑卿勇,许建国,崔雅婷,姚进龙,王盼,刘爱萍..康艾注射液调控肠道微生物代谢物干预结直肠癌的机制研究[J].医学信息,2026,39(15):29-34,6.基金项目
甘肃省高校教师创新基金项目(编号:2025A-402) （编号:2025A-402）
