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Immune profile and mitochondrial alterations driven by age and HIV infection:Associations with T-cell senescence in people with HIV receiving suppressive antiretroviral therapy

Junyan Jin Xin Zhang Qianqian Xu Wei Xia Hongxia Yan Hao Wu Christiane Moog Tong Zhang Bin Su

中国病毒学2026，Vol.41Issue(3)：561-573,13.
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中国病毒学2026，Vol.41Issue(3)：561-573,13.DOI:10.1016/j.virs.2026.05.001

Immune profile and mitochondrial alterations driven by age and HIV infection:Associations with T-cell senescence in people with HIV receiving suppressive antiretroviral therapy

Immune profile and mitochondrial alterations driven by age and HIV infection:Associations with T-cell senescence in people with HIV receiving suppressive antiretroviral therapy

Junyan Jin 1Xin Zhang 1Qianqian Xu 1Wei Xia 1Hongxia Yan 1Hao Wu 1Christiane Moog 2Tong Zhang 1Bin Su3

作者信息

  • 1. Beijing Key Laboratory for HIV/AIDS Research,Clinical and Research Center for Infectious Diseases,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China||Sino-French Joint Laboratory for HIV/AIDS Research,Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China
  • 2. Sino-French Joint Laboratory for HIV/AIDS Research,Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China||Laboratoire d'ImmunoRhumatologie Moléculaire,Institut National de la Santé et de la Recherche Médicale(INSERM)UMR_S 1109,Institut Thématique Interdisciplinaire(ITI)de Médecine de Précision de Strasbourg,Transplantex NG,Faculté de Médecine,Fédération Hospitalo-Universitaire OMICARE,Fédération de Médecine Translationnelle de Strasbourg(FMTS),Université de Strasbourg,Strasbourg,67000,France
  • 3. Beijing Key Laboratory for HIV/AIDS Research,Clinical and Research Center for Infectious Diseases,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China||Sino-French Joint Laboratory for HIV/AIDS Research,Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China||Central Laboratory,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China||The Scientific and Technological Achievement Transformation Center,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China
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摘要

关键词

HIV infection/Ageing/Immunosenescence/T cells/Mitochondrial dysfunction

Key words

HIV infection/Ageing/Immunosenescence/T cells/Mitochondrial dysfunction

引用本文复制引用

Junyan Jin,Xin Zhang,Qianqian Xu,Wei Xia,Hongxia Yan,Hao Wu,Christiane Moog,Tong Zhang,Bin Su..Immune profile and mitochondrial alterations driven by age and HIV infection:Associations with T-cell senescence in people with HIV receiving suppressive antiretroviral therapy[J].中国病毒学,2026,41(3):561-573,13.

基金项目

This work was supported by the National Natural Science Foundation of China(NSFC,82472266 to B.S.),the National Key R&D Program of China(2023YFE0116000,2023YFC2308300,2023YFC2308302 to B.S.),the Beijing High-Level Innovation and Entrepreneurship Talent Support Program-Leading Talent Projects(G202512065 to B.S.),the Public Health Talent Training and Support Program of the National Disease Control and Prevention Administration(to B.S.),and the Beijing Key Laboratory for HIV/AIDS Research(BZ0089 to B.S.).The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript. （NSFC,82472266 to B.S.）

中国病毒学

1003-5125

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