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首页|期刊导航|中国病毒学|Induction of mitochondrial fission and mtDNA leakage via the Smad3/Drp1 axis by PEDV infection activates the TLR9/NF-κB/IL-1β inflammatory pathway

Induction of mitochondrial fission and mtDNA leakage via the Smad3/Drp1 axis by PEDV infection activates the TLR9/NF-κB/IL-1β inflammatory pathway

Hangao Xie Ruiai Chen Jinlian Guan Fengjie Tian Ting Xiong Haixia Feng Fei Xu Ziqing Zhou Dongsheng He Dingxiang Liu

中国病毒学2026，Vol.41Issue(3)：586-601,16.
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中国病毒学2026，Vol.41Issue(3)：586-601,16.DOI:10.1016/j.virs.2026.05.004

Induction of mitochondrial fission and mtDNA leakage via the Smad3/Drp1 axis by PEDV infection activates the TLR9/NF-κB/IL-1β inflammatory pathway

Induction of mitochondrial fission and mtDNA leakage via the Smad3/Drp1 axis by PEDV infection activates the TLR9/NF-κB/IL-1β inflammatory pathway

Hangao Xie 1Ruiai Chen 1Jinlian Guan 1Fengjie Tian 1Ting Xiong 1Haixia Feng 2Fei Xu 2Ziqing Zhou 2Dongsheng He 1Dingxiang Liu1

作者信息

  • 1. College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China||Zhaoqing Branch Centre of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology,Zhaoqing 526200,China
  • 2. College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China
  • 折叠

摘要

关键词

Porcine epidemic diarrhea virus(PEDV)/Mitochondrial fission/mtDNA leakage/Smad3/Drp1 axis/Inflammatory responses

Key words

Porcine epidemic diarrhea virus(PEDV)/Mitochondrial fission/mtDNA leakage/Smad3/Drp1 axis/Inflammatory responses

引用本文复制引用

Hangao Xie,Ruiai Chen,Jinlian Guan,Fengjie Tian,Ting Xiong,Haixia Feng,Fei Xu,Ziqing Zhou,Dongsheng He,Dingxiang Liu..Induction of mitochondrial fission and mtDNA leakage via the Smad3/Drp1 axis by PEDV infection activates the TLR9/NF-κB/IL-1β inflammatory pathway[J].中国病毒学,2026,41(3):586-601,16.

基金项目

Funding for this research was provided by the Research and devel-opment program in key areas of Guangdong Province(2021B0707010009),the Zhaoqing Science and Technology Projects(2021C001),the Zhaoqing Xijiang Innovative Team Foundation of China(P20211154-0202),and the Independent project of Zhaoqing Branch Center of Guangdong Laboratory for Lingnan Modern Agricul-tural Science and Technology(P20211154-0105). （2021B0707010009）

中国病毒学

1003-5125

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