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ASFV pA137R protein triggers inflammatory response by inducing NF-κB signaling pathway and facilitating NLRP3 inflammasome assembly

Yi Zeng Xiaohong Liu Siqi Dong Hanyu Wu Li Huang Changjiang Weng

中国病毒学2026，Vol.41Issue(3)：602-611,10.
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中国病毒学2026，Vol.41Issue(3)：602-611,10.DOI:10.1016/j.virs.2026.05.008

ASFV pA137R protein triggers inflammatory response by inducing NF-κB signaling pathway and facilitating NLRP3 inflammasome assembly

ASFV pA137R protein triggers inflammatory response by inducing NF-κB signaling pathway and facilitating NLRP3 inflammasome assembly

Yi Zeng 1Xiaohong Liu 1Siqi Dong 1Hanyu Wu 1Li Huang 2Changjiang Weng2

作者信息

  • 1. Division of Fundamental Immunology,Professional Laboratory for African Swine Fever(Harbin),State Key Laboratory for Animal Disease Control and Prevention,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150069,China
  • 2. Division of Fundamental Immunology,Professional Laboratory for African Swine Fever(Harbin),State Key Laboratory for Animal Disease Control and Prevention,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150069,China||Heilongjiang Provincial Key Laboratory of Veterinary Immunology,Harbin 150069,China
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摘要

关键词

African swine fever virus(ASFV)/pA137R protein/NF-κB pathway/NLRP3 inflammasome

Key words

African swine fever virus(ASFV)/pA137R protein/NF-κB pathway/NLRP3 inflammasome

引用本文复制引用

Yi Zeng,Xiaohong Liu,Siqi Dong,Hanyu Wu,Li Huang,Changjiang Weng..ASFV pA137R protein triggers inflammatory response by inducing NF-κB signaling pathway and facilitating NLRP3 inflammasome assembly[J].中国病毒学,2026,41(3):602-611,10.

基金项目

We would like to thank the Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,and all staffs of Division of Fundamental Immunology,Professional Laboratory for African Swine Fever(Harbin).This study was supported by the National Natural Sci-ence Foundation of China(grants No.32322081,32270156),Natural Science Foundation of Heilongjiang Province of China(ZD2025C009),Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-CSLPDCP-202401,CAAS-CSLPDCP-2023002),Central Public-interest Scientific Institution Basal Research Fund(Y2025YC123). （Harbin）

中国病毒学

1003-5125

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