中国肺癌杂志2026，Vol.29Issue(6)：437-444,8.DOI:10.3779/j.issn.1009-3419.2026.102.19
肺腺癌脊柱定向转移的分子机制与精准诊疗研究进展
Research Progress on Molecular Mechanisms and Precision Diagnosis and Treatment of Spinal Organotropic Metastasis in Lung Adenocarcinoma
摘要
Abstract
Lung adenocarcinoma(LUAD)is the most common subtype of non-small cell lung cancer(NSCLC),with a high incidence of spinal metastasis and poor prognosis.Spinal metastasis of LUAD is not merely a simple bone metas-tasis but a directed metastasis process mediated by the anatomical characteristics of the spine,microenvironment specificity,and molecular regulatory mechanisms.However,current research mainly focuses on general bone metastasis,and a dedicated mechanism and precise diagnosis and treatment system for spinal-directed metastasis have not yet been established.Therefore,this article systematically elaborates on the molecular mechanisms of LUAD spinal-directed metastasis from three key aspects:metastatic potential,microenvironment regulation,and metastasis pathways.Combined with the clinical characteristics of spi-nal metastasis and the current research deficiencies,it provides new ideas for basic research and clinical precise prevention and treatment of LUAD spinal metastasis.关键词
肺肿瘤/脊柱定向转移/脊柱微环境/精准诊疗Key words
Lung neoplasms/Spinal organotropic metastasis/Spinal microenvironment/Precision therapy引用本文复制引用
付弘扬,折依侗,李芒来,杜一鸣,祝勇..肺腺癌脊柱定向转移的分子机制与精准诊疗研究进展[J].中国肺癌杂志,2026,29(6):437-444,8.基金项目
This paper was supported by the grants from the Key Project of Inner Mongolia Hospital,Peking University Cancer Hospital(No.2024YNZD003,to Yong ZHU),Public Hospital Scientific Research Joint Fund Project of Inner Mongolia Acad-emy of Medical Sciences(No.2025GLLH0269,to Yong ZHU),and Science and Technology Planning Project of Inner Mongo-lia Autonomous Region(No.2026YFSH0108,to Yong ZHU).本文受北京大学肿瘤医院内蒙古医院重点项目(No.2024YNZD003)、内蒙古医学科学院公立医院科研联合基金科技项目(No.2025GLLH0269)和内蒙古自治区科技计划项目(No.2026YFSH0108)资助 （No.2024YNZD003,to Yong ZHU）
