中国肺癌杂志2026，Vol.29Issue(6)：445-452,8.DOI:10.3779/j.issn.1009-3419.2026.102.20
肺癌类器官的规范化构建及其在肺癌精准诊疗中的应用进展
Standardized Construction of Lung Cancer Organoids and Their Application Progress in the Precise Treatment of Lung Cancer
摘要
Abstract
Lung cancer is the malignancy with the highest incidence and mortality rates in China.Although signifi-cant progress has been made in its treatment due to the application of various novel therapeutic approaches,challenges remain in early diagnosis,as more than half of patients present with distant metastases at diagnosis,indicating a substantial gap com-pared to ideal precision therapy.Therefore,there is an urgent need to develop a novel personalized diagnostic and therapeutic model.Traditional cancer cell line models lack spatial structure and fail to accurately replicate the growth dynamics of native tissues;patient-derived xenograftmodels are costly and exhibit low transplantation success rates.In contrast,lung cancer organ-oids(LCOs)demonstrate superior genetic stability and rapid culture efficiency compared to other models,faithfully simulating the natural growth patterns of primary tumors and reducing animal dependency,making them particularly suitable for large-scale drug screening.However,despite rapid advancements in organoid technology,consensus has yet to be reached regarding standardized LCOs construction methods.This article systematically outlines the standardized development of LCOs models,their applications in precision lung cancer diagnosis and treatment,and recent progress,aiming to guide clinical implementa-tion and improve patients'quality of life and survival outcomes.关键词
肺肿瘤/肺癌类器官/药物敏感性检测/肿瘤微环境Key words
Lung neoplasms/Lung cancer organoids/Drug sensitivity testing/Tumor microenvironment引用本文复制引用
曹森,李文,张晓宽,牛天翼,吴峥,汪治宇..肺癌类器官的规范化构建及其在肺癌精准诊疗中的应用进展[J].中国肺癌杂志,2026,29(6):445-452,8.基金项目
This paper was supported by the grants from the National Natural Science Foundation of China(No.81872101,to Zhiyu WANG)and the Natural Science Foundation of Hebei Province(No.H2024206210,to Zhiyu WANG). 本文受国家自然科学基金项目(No.81872101)和河北省自然科学基金项目(No.H2024206210)资助 （No.81872101,to Zhiyu WANG）
