中国肺癌杂志2026，Vol.29Issue(6)：453-461,9.DOI:10.3779/j.issn.1009-3419.2026.101.13
GPER介导的大气细颗粒物致肺癌作用研究进展
Research Advances in the Pulmonary Carcinogenic Effects of Atmospheric Fine Particulate Matter Mediated by GPER
摘要
Abstract
Lung cancer remains the leading cause of cancer-related death worldwide.Fine particulate matter(PM2.5),classified as a group I human carcinogen,has been extensively linked to lung cancer development through epidemiological studies.The G protein-coupled estrogen receptor(GPER)can be activated and induce tumorigenesis by environmental pol-lutants,and it is significantly overexpressed in lung cancer tissues,highlighting its critical role in disease progression.Research indicates that environmental estrogen-like components and metal ions in PM2.5 can activate GPER,thereby regulating down-stream signaling pathways such as mitogen-activated protein kinase/extracellular signal-regulated kinase(MAPK/ERK)and phosphoinositide 3-kinase/protein kinase B(PI3K/AKT).This activation triggers inflammatory responses,oxidative stress,and ferroptosis,ultimately promoting tumor cell proliferation,apoptosis,migration,epithelial-mesenchymal transition,and remodeling of the tumor microenvironment.Collectively,these mechanisms drive the initiation and progression of lung can-cer.In summary,GPER serves as a pivotal molecular hub connecting PM2.5 exposure to lung cancer pathogenesis,presenting a promising therapeutic target.Inhibitors targeting GPER may offer novel strategies for the prevention and treatment of lung cancer.关键词
肺肿瘤/G蛋白偶联雌激素受体/大气细颗粒物/呼吸系统Key words
Lung neoplasms/G protein-coupled estrogen receptor/Fine particulate matter/Respiratory system引用本文复制引用
李振华,李定彪..GPER介导的大气细颗粒物致肺癌作用研究进展[J].中国肺癌杂志,2026,29(6):453-461,9.基金项目
This paper was supported by the grants from the National Natural Science Foundation of China(No.82460698,to Dingbiao LI)and Yunnan Provincial Department of Science and Technology-Kunming Medical University Special Projects(No.202301AY070001-173,to Zhenhua LI). 本文受国家自然科学基金(No.82460698)与云南省科技厅-昆明医科大学基础研究联合专项(No.202301AY070001-173)资助 （No.82460698,to Dingbiao LI）
