中国康复理论与实践2026，Vol.32Issue(8)：892-902,11.DOI:10.3969/j.issn.1006-9771.2026.08.003
慢性疲劳综合征肌肉病理生理的Scoping综述
Pathophysiology in muscle fatigue in myalgic encephalomyelitis/chronic fatigue syndrome:a scoping review
王子龙 1李宏玉 2王志浩 1李洪欣 1江莹莹 1唐强2
作者信息
- 1. 黑龙江中医药大学,黑龙江 哈尔滨市 150040
- 2. 黑龙江中医药大学,黑龙江 哈尔滨市 150040||黑龙江中医药大学附属第二医院,黑龙江 哈尔滨市 150001
- 折叠
摘要
Abstract
Objective To systematically summarize the relevant pathophysiology underlying muscle fatigue in myalgic encephalo-myelitis/chronic fatigue syndrome(ME/CFS).
Methods Databases including PubMed,Web of Science Core Collection,Embase,Cochrane Library,EBSCO(CI-NAHL),CNKI,Wanfang Data and VIP Database were searched from their inception to July,2025 for basic and clinical studies related to ME/CFS.Multidimensional evidence involving mitochondrial,neuromuscular junction dysfunction,autonomic dysregulation and immune-inflammatory responses was integrated.The role of muscles in the central-immune-metabolic-neural regulatory network and its association with clinical phenotypes were evaluated.
Results Patients with ME/CFS commonly presented with impaired mitochondrial energy supply,oxidative stress,ion ho-meostasis disorders,reduced stability of neuromuscular junction transmission,insufficient central drive and pos-tural intolerance.These abnormalities resulted in a predisposition to cross the anaerobic threshold and trigger post-exertional malaise.
Conclusion Muscle pathophysiology plays a critical role in the pathogenesis and symptom persistence of ME/CFS.Re-habilitation practice should prioritize safety boundaries to avoid post-exertional malaise.关键词
慢性疲劳综合征/肌肉疲劳/病理生理/Scoping综述Key words
chronic fatigue syndrome/muscle fatigue/pathophysiology/scoping review分类
医药卫生引用本文复制引用
王子龙,李宏玉,王志浩,李洪欣,江莹莹,唐强..慢性疲劳综合征肌肉病理生理的Scoping综述[J].中国康复理论与实践,2026,32(8):892-902,11.
