中国临床医学2026，Vol.33Issue(4)：636-642,7.DOI:10.12025/j.issn.1008-6358.2026.20260399
糖尿病视网膜病变患者的代谢特征及影响因素
Metabolic characteristics and related influencing factors in patients with diabetic retinopathy
摘要
Abstract
Objective To explore the metabolic characteristics and related factors in patients with diabetic retinopathy(DR).Methods A retrospective study was conducted on the clinical data of 467 diabetic patients hospitalized at the Affiliated Hospital of Nanjing University of Chinese Medicine from January 2020 to September 2024.The patients were divided into the DR group(n=150)and the non-DR group(n=317).Liver stiffness measurement(LSM)and controlled attenuation parameter(CAP)were assessed using a transient elastography device,and graded into five levels.Basic data,LSM and CAP grading,and metabolic indicators were compared between the two groups.Univariate and multivariate logistic regression analyses were applied to identify factors influencing DR.Results Patients in the DR group were older than those in the non-DR group(P＜0.001).Compared with the non-DR group,fasting blood glucose(FBG),glycated hemoglobin A1C(HbA1C),and triglyceride(TG)levels were higher,while low-density lipoprotein cholesterol(LDL-C)was lower in the DR group(P＜0.05).Significant differences in LSM grading were observed between the two groups(P=0.006).Multivariate logistic regression analysis revealed that LSM grading(grade 2:OR=2.127,P=0.002;grade 3:OR=2.344,P=0.030;grade 4:OR=2.960,P=0.038),FBG(OR=1.233,P＜0.001),and serum creatinine(OR=1.013,P=0.006)were independent factors associated with DR.Conclusions FBG,serum creatinine,and LSM are related factors of DR.In clinical practice,attention should be paid to the coordinated management of blood glucose control,renal function monitoring,and liver fibrosis assessment,with early interventions to reduce the risk of DR.关键词
糖尿病/糖尿病视网膜病变/代谢特征/影响因素Key words
diabetes mellitus/diabetic retinopathy/metabolic characteristic/influencing factor分类
医药卫生引用本文复制引用
刘思漫,孙心怡,葛静,余旭,缪鋆鋆..糖尿病视网膜病变患者的代谢特征及影响因素[J].中国临床医学,2026,33(4):636-642,7.基金项目
江苏省中医药管理局项目(MS2021009).Supported by Project of Jiangsu Provincial Administration of Traditional Chinese Medicine(MS2021009). （MS2021009）
