中国输血杂志2026，Vol.39Issue(8)：1012-1017,6.DOI:10.13303/j.cjbt.issn.1004-549x.2026.08.003
丹酚酸 B 对保存红细胞质量的影响及机制探究
Effect of salvianolic acid B on the stored red blood cell quality and its underlying mechanism
摘要
Abstract
Objective To investigate the effects of salvianolic acid B(Sal B)on the quality of stored red blood cells(RBC)and to preliminarily explore its underlying mechanisms.Methods Whole blood was collected from healthy adult volunteers,and suspended RBC were prepared and stored in MAP(mannitol-adenine-phosphate)solution.The RBC sus-pensions were divided into a control group and a Sal B group,with the latter supplemented with Sal B at a final concentration of 10 μM.All samples were mixed and stored at 2-6℃.RBC were collected on days 0,7,14,21,28,and 35 for evalua-tion.RBC damage was assessed through cell counting,morphological observation,osmotic fragility test,and hemolysis rate measurement.Cytosolic ROS levels and intracellular SOD activity were measured to evaluate oxidative stress.Results Sal B helped maintain RBC morphology and osmotic stability,and reduced the generation of morphologically abnormal cells such as spherocytes and echinocytes.On days 28 and 35,the hemolysis rate in the Sal B group was significantly lower than that in the control group.Compared with the control group,the Sal B group exhibited decreased cytosolic ROS levels and in-creased intracellular SOD activity from day 14 onward.Conclusion Sal B alleviates RBC storage lesion by reducing oxida-tive stress.关键词
丹酚酸 B/红细胞保存/氧化应激/存储损伤Key words
salvianolic acid B(Sal B)/red blood cell storage/oxidative stress/storage lesion分类
医药卫生引用本文复制引用
陈传爱,李浩泷,安蓬蓬,杨育淼,于洋..丹酚酸 B 对保存红细胞质量的影响及机制探究[J].中国输血杂志,2026,39(8):1012-1017,6.基金项目
天津市卫生健康科技项目资助(TJWJ2023MS049) （TJWJ2023MS049）
