中国比较医学杂志2026，Vol.36Issue(13)：81-95,15.DOI:10.3969/j.issn.1671-7856.2026.13.007
城市化背景下腹泻型肠易激综合征与代谢综合征的共病机制
The comorbidity mechanism of diarrhea predominant irritable bowel syndrome and metabolic syndrome in the context of urbanization
摘要
Abstract
In an urbanized society,changes in dietary patterns and increased life stress have led to a steady annual rise in the incidence of diarrhea predominant irritable bowel syndrome(IBS-D),substantially impairing patients' quality of life.Concurrently,metabolic disorders such as obesity,diabetes,and metabolic dysfunction-associted steatotic liver disease are also increasing,and multisystem damage associated with metabolic syndrome(MetS)has drawn considerable research attention.Although the independent pathogenesis of each condition is well recognized,the pathological mechanisms and physiological interactions underlying their comorbidity remain unclear.Accordingly,this review uses the brain-gut axis imbalance as a conceptual framework to systematically synthesize and summarize the current evidence on their co-occurrence.In addition,we explore the traditional Chinese medicine theory of"treating different diseases with the same approach"from the perspective that the spleen governs transportation and transformation.This integrative perspective aims to overcome current therapeutic bottleneck in managing IBS-D and MetS comorbidity,optimize clinical management strategies,and offer insights and references for the integration of Chinese and Western medicine.关键词
城市化/腹泻型肠易激综合征/代谢综合征/共病机制/脾主运化Key words
urbanization/diarrhea predominant irritable bowel syndrome/metabolic syndrome/comorbidity mechanism/spleen governs transportation and transformation分类
医药卫生引用本文复制引用
温晓晴,潘海迪,贺昌辉,窦鑫,邓华亮,王伟..城市化背景下腹泻型肠易激综合征与代谢综合征的共病机制[J].中国比较医学杂志,2026,36(13):81-95,15.基金项目
国家自然科学基金青年基金(81904128) （81904128）
国家中医药管理局科技司共建科技项目(GZY-KJS-SD-2023-035) （GZY-KJS-SD-2023-035）
山东省中医药疗效机理重点实验室项目(PKL2024C23) （PKL2024C23）
山东省中医药重点学科中医脾胃病学(鲁卫中医药科教字[2022]4号) （鲁卫中医药科教字[2022]4号）
山东省重点研发计划(竞争性创新平台)项目(2025CXPT147). （竞争性创新平台）
