中国实用儿科杂志2026，Vol.41Issue(7)：529-537,9.DOI:10.19538/j.ek2026070601
慢性肉芽肿病临床管理与预防接种专家共识
Expert consensus on clinical management and vaccination for chronic granulomatous disease
摘要
Abstract
Chronic granulomatous disease(CGD)is an inborn error of immunity caused by phagocyte dysfunction.Due to NADPH oxidase deficiency,phagocytes are unable to generate superoxide anions(O2)normally,leading to recurrent and severe bacterial and fungal infections accompanied by granuloma formation.Currently,there is a lack of standardized consensus or guidelines for the systematic management and vaccination for CGD.Group of Immunology of the Society of Pediatrics of Chinese Medical Association and Inborn Errors of Immunity Alliance of National Children's Medical and Clinical Research Center(IEI.CHN)have organized experts to develop this consensus based on existing evidence and clinical practice experience.The consensus addresses 10 common clinical issues related to CGD and formulates 18 recommendations,aiming to provide a reference for the diagnosis,treatment,and long-term follow-up management of CGD.关键词
慢性肉芽肿病/出生免疫缺陷/感染/造血干细胞移植/预防接种Key words
chronic granulomatous disease/inborn errors of immunity/infection/HSCT/vaccination分类
医药卫生引用本文复制引用
中华医学会儿科学分会免疫学组,国家儿童医学暨临床研究中心IEI联盟,孙金峤,王晓川..慢性肉芽肿病临床管理与预防接种专家共识[J].中国实用儿科杂志,2026,41(7):529-537,9.基金项目
国家重点研发计划(2022YFC2704905) （2022YFC2704905）
上海市市级科技重大专项"重大突发传染病防控关键核心技术研究"(ZD2021CY001) （ZD2021CY001）
