中国实用儿科杂志2026，Vol.41Issue(7)：538-553,16.DOI:10.19538/j.ek2026070602
拉考沙胺治疗儿童癫痫发作的精准用药专家共识(2026)
Expert consensus on precision medication of lacosamide in the treatment of children with epilepsy
摘要
Abstract
Epilepsy is one of the most prevalent chronic neurological disorders in the pediatric population.As a third-generation antiseizure medication with a unique pharmacological mechanism and good safety,lacosamide(LCM)has provided a new option for pediatric epilepsy management.However,the pharmacokinetics(PK)profile of LCM in children exhibits substantial inter-individual variability because of the fact that children are at the stage of rapid growth and development,highlighting an urgent need for standardized clinical guidance.Initiated by the Division of Therapeutic Drug Monitoring,Chinese Pharmacological Society,and led by the Children's Hospital of Nanjing Medical University,this consensus has strictly followed the 2022 Edition of the Guideline for the Development and Revision of Clinical Practice Guidelines in China,and registered in the PREPARE registry(PREPARE-2026CN141).The consensus development group systematically retrieved relevant clinical evidence published from 2005 to 2026 across major Chinese and English academic databases.Based on the evidence grading and recomendation strength criteria made by Oxford Centre for Evidence-Based Medicine(2009),and after Delphi expert consultations and anonymous voting,a total of 21 recommendations were finally formulated,covering the clinical application,PK characteristics,pharmacogenomics,therapeutic drug monitoring(TDM),and model-informed precision dosing(MIPD)of LCM in children with epilepsy.This consensus establishes a preliminary TDM target concentration range of 2-10 μ g/mL for LCM in Chinese pediatric patients,and proposes a standardized MIPD workflow.The aim is to provide clinicians and pharmacists with scientific and standardized guidance for individualized medication and improve the safety and efficacy of LCM treatment for pediatric epilepsy.关键词
癫痫/儿童/拉考沙胺/精准用药/专家共识Key words
epilepsy/children/lacosamide/precision medication/expert consensus分类
医药卫生引用本文复制引用
中华医学会儿科学分会临床药理学组,江苏省药理学会治疗药物监测研究专业委员会,《中国实用儿科杂志》编辑委员会,陈峰,王晓玲,卢孝鹏..拉考沙胺治疗儿童癫痫发作的精准用药专家共识(2026)[J].中国实用儿科杂志,2026,41(7):538-553,16.基金项目
国家重点研发计划(2023YFC2706100) （2023YFC2706100）
中华医学会临床药学专项科研基金(Z-2021-46-2503 （）
Z-2021-46-2101) （）
