中国实用内科杂志2026，Vol.46Issue(7)：537-543,7.DOI:10.19538/j.nk2026070102
全反式维甲酸联合砷剂时代急性早幼粒细胞白血病治疗进展
Advances in the treatment of acute promyelocytic leukemia in the era of ATRA plus Arsenic-based therapy
摘要
Abstract
The combination of all-trans retinoic acid(ATRA)and arsenic-based therapy has markedly improved outcomes in acute promyelocytic leukemia(APL),driving a shift in APL management toward treatment simplification,reduced toxicity,and greater precision.This review focuses on the major therapeutic advances in APL in the era of ATRA plus arsenic-based therapy,with particular emphasis on optimization of front-line strategies,progress in the management of relapsed/refractory disease,and evolving molecular insights and therapeutic approaches in variant APL and APL-like leukemia.It also aims to provide a useful reference for clinical practice and future research.关键词
急性早幼粒细胞白血病/全反式维甲酸/三氧化二砷/早期死亡/复发难治/变异型急性早幼粒细胞白血病/靶向治疗Key words
acute promyelocytic leukemia/all-trans retinoic acid/arsenic trioxide/early death/relapsed/refractory disease/variant acute promyelocytic leukemia/targeted therapy分类
医药卫生引用本文复制引用
陈丽..全反式维甲酸联合砷剂时代急性早幼粒细胞白血病治疗进展[J].中国实用内科杂志,2026,46(7):537-543,7.基金项目
上海市血液病学临床专科能力提升项目(SHDC22024314) （SHDC22024314）
