中国医科大学学报2026，Vol.55Issue(8)：728-733,6.DOI:10.12007/j.issn.0258-4646.2026.08.009
紫草素调控PTEN/AKT/TFEB信号通路改善心肌梗死大鼠心室重构
Shikonin modulates PTEN/AKT/TFEB signaling pathway to improve ventricular remodeling in myocardial infarction rats
摘要
Abstract
Objective To investigate the mechanism by which shikonin(SK)improves ventricular remodeling in myocardial infarc-tion(MI)by modulating the phosphatase and tensin homolog(PTEN)/protein kinase B(AKT)/transcription factor EB(TFEB)signaling pathway.Methods SD rats were randomly divided into Sham,MI,L-SK,H-SK,and H-SK+BpV groups(n=10 each).Cardiac function,myocardial histopathology,serum inflammatory factor levels,and protein expressions were assessed via echocardiography,histological staining,ELISA,and Western blotting.Results Compared with Sham group,MI group exhibited increased myocardial fibrosis,inflamma-tory infiltration,and deteriorated cardiac function.Compared with the MI group,SK-treated groups(L-SK,H-SK)showed reduced myocar-dial injury and fibrosis,and improved cardiac function in a dose-dependent manner,along with significant changes in PTEN/AKT/TFEB and autophagy-related proteins.The H-SK+BpV group demonstrated opposite trends.Conclusion SK may improve cardiac function and attenuate myocardial injury and fibrosis in MI rats by modulating the PTEN/AKT/TFEB signaling pathway,suppressing inflammation,and activating cardiomyocyte autophagy.关键词
紫草素/心肌梗死/心室重构/PTEN/AKT/TFEB信号通路/自噬/炎症Key words
shikonin/myocardial infarction/ventricular remodeling/PTEN/AKT/TFEB signaling pathway/autophagy/inflammation分类
医药卫生引用本文复制引用
徐乐,刘纬,陈伟广,温德惠..紫草素调控PTEN/AKT/TFEB信号通路改善心肌梗死大鼠心室重构[J].中国医科大学学报,2026,55(8):728-733,6.基金项目
河北省医学科学研究课题计划(20211139) （20211139）
