中国医学创新2026，Vol.23Issue(19)：30-34,5.DOI:10.3969/j.issn.1674-4985.2026.19.007
中西医结合疗法治疗维持性血液透析患者EPO抵抗(脾肾阳虚证)的效果
The Effect of Integrated Traditional Chinese and Western Medicine Therapy on Maintenance Hemodialysis Patients with EPO Resistance(Spleen and Kidney Yang Deficiency Syndrome)
摘要
Abstract
Objective:To explore the clinical effect of integrated traditional Chinese and western medicine therapy in the treatment of maintenance hemodialysis(MHD)patients with Erythropoietin(EPO)resistance(spleen and kidney Yang deficiency syndrome).Method:A total of 70 MHD patients with EPO resistance(spleen and kidney Yang deficiency syndrome)admitted to Ganzhou Municipal Hospital from February 2022 to February 2025 were prospectively selected and divided into the control group(n=35)and the observation group(n=35)according to the random number table method.The control group was treated with EPO combined with Polysaccharide Iron Complex,while the observation group was treated with integrated traditional Chinese and western medicine therapy(Roxadustat,Polysaccharide Iron Complex and Shengxuening Tablets).The treatment course for both groups was 3 months.The clinical efficacy,anemia indicators,traditional Chinese medicine syndrome scores,inflammatory factors,iron metabolism indicators and the incidence of adverse reactions of the two groups were compared.Result:After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the main symptom score,secondary symptom score and total score of the traditional Chinese medicine syndrome score in the observation group were all lower than those in the control group,while the levels of hemoglobin,hematocrit,serum iron,transferrin saturation and ferritin in the observation group were higher than those in the control group,and the levels of nuclear factor-κB and interferon-γ were lower than those in the control group(P<0.05).The comparison of the incidence of adverse reactions between the two groups showed no statistically significant difference(P>0.05).Conclusion:MHD patients with EPO resistance(spleen and kidney Yang deficiency syndrome)have shown remarkable therapeutic effects when treated with integrated traditional Chinese and western medicine therapy.It can effectively improve their anemia-related indicators and has good safety.关键词
中西医结合疗法/维持性血液透析/促红细胞生成素抵抗Key words
Integrated traditional Chinese and western medicine therapy/Maintenance hemodialysis/Erythropoietin resistance分类
医药卫生引用本文复制引用
毛青华,谢强,曾健华,钟丹..中西医结合疗法治疗维持性血液透析患者EPO抵抗(脾肾阳虚证)的效果[J].中国医学创新,2026,23(19):30-34,5.基金项目
赣州市卫生健康委员会市级科研计划项目(GZWJW202502502) （GZWJW202502502）
