中国医学创新2026，Vol.23Issue(19)：39-43,5.DOI:10.3969/j.issn.1674-4985.2026.19.009
负压封闭引流、自体刃厚皮复合移植联合抗生素骨水泥在四肢难愈性创面中的临床应用研究
Clinical Application Research of Vacuum Sealing Drainage,Autologous Split-thickness Skin Grafting Combined with Antibiotic Bone Cement in the Treatment of Refractory Wounds of the Extremities
摘要
Abstract
Objective:To investigate the clinical application efficacy of vacuum sealing drainage,autologous split-thickness skin grafting combined with antibiotic bone cement in the treatment of refractory wounds of the extremities.Method:A total of 60 patients with refractory wounds of the extremities admitted to Panyu Central Hospital,Guangzhou Medical University from January 2024 to March 2025 were selected and randomly divided into a control group(30 cases)and an experimental group(30 cases).The control group was given vacuum sealing drainage combined with autologous split-thickness skin grafting,while the experimental group was treated with antibiotic bone cement on the basis of the control group.The number of dressing changes,wound healing rate,hospital stay,general comfort questionnaire(GCQ)score,VAS score,CRP,white blood cell count,procalcitonin(PCT),erythrocyte sedimentation rate(ESR),and ADL score of the two groups were compared.Result:The number of dressing changes in the experimental group was less than that in the control group,the hospital stay was shorter than that in the control group,and the wound healing rate after 2 weeks treatment was higher than that in the control group(P<0.05).After 2 weeks of treatment,the GCQ score of the experimental group was higher than that of the control group,and the VAS score was lower than that of the control group(P<0.05).After 2 weeks of treatment,the CRP,white blood cell count,PCT,and ESR of the experimental group were lower than those of the control group(P<0.05).After 2 weeks of treatment,the ADL score of the experimental group was higher than that of the control group(P<0.05).Conclusion:The clinical application effect of vacuum sealing drainage,autologous split-thickness skin grafting combined with antibiotic bone cement in the treatment of refractory wounds of the extremities is definite.It can increase comfort,alleviate pain,inhibit inflammatory response,promote wound healing and enhance the quality of life.关键词
抗生素骨水泥/负压封闭引流/自体刃厚皮复合移植/四肢难愈性创面/创面愈合Key words
Antibiotic bone cement/Vacuum sealing drainage/Autologous split-thickness skin grafting/Refractory wounds of the extremities/Wound healing分类
医药卫生引用本文复制引用
周云,崔宏宇,侯雷,冯景浩,王永胜,王波,李军..负压封闭引流、自体刃厚皮复合移植联合抗生素骨水泥在四肢难愈性创面中的临床应用研究[J].中国医学创新,2026,23(19):39-43,5.基金项目
2025年度广东省医学科研基金指令性课题项目(C2025052) （C2025052）
2023年番禺区科技计划一般医疗卫生项目(2023-Z04-055) （2023-Z04-055）
