中国医学创新2026，Vol.23Issue(21)：16-20,5.DOI:10.3969/j.issn.1674-4985.2026.21.004
替罗非班序贯双联抗血小板治疗在进展性缺血性脑卒中的应用效果
Clinical Efficacy of Tirofiban Sequential Dual Antiplatelet Therapy in Progressive Ischemic Stroke
摘要
Abstract
Objective:To evaluate the clinical efficacy of Tirofiban sequential dual antiplatelet therapy in patients with progressive ischemic stroke and its impact on neurological function.Method:A prospective randomized controlled study was conducted,160 patients with progressive ischemic stroke admitted to the Department of Neurology,the Second Affiliated Hospital of Guangdong Medical University from August 2024 to November 2025 were selected.Patients were divided into the control group(80 cases,treated with Aspirin combined with Clopidogrel Bisulfate)and the study group(80 cases,treated with Tirofiban sequential dual antiplatelet therapy)using a random number table.Both groups received standard basic treatment for ischemic stroke.The overall therapeutic effect,degree of neurological deficit,activities of daily living,levels of inflammatory factors,and platelet function indices were compared between the two groups.Additionally,the incidence of adverse reactions during treatment was recorded.Result:The total effective rate of the study group at 90th days of treatment was 93.75%,which was significantly higher than that of the control group(77.50%)(P<0.05).The NIHSS scores of both groups were significantly reduced at 7th,30th,and 90th days of treatment compared with those before treatment,and the BI scores were significantly higher,the NIHSS scores of the study group were lower than those of the control group,and the BI scores were higher than those of the control group(P<0.05).The levels of inflammatory factors(TNF-α,IL-6,hs-CRP)and platelet activation indicators[platelet α-granule membrane protein 140(GMP-140),thromboxane B2(TXB2)]in the study group were lower than those in the control group at 7th days of treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For patients with progressive ischemic stroke,sequential application of Tirofiban on the basis of standard dual antiplatelet therapy can more effectively improve neurological deficit and enhance activities of daily living without significantly increasing the risk of adverse reactions.关键词
替罗非班/序贯双联抗血小板治疗/进展性缺血性脑卒中/神经功能Key words
Tirofiban/Sequential dual antiplatelet therapy/Progressive ischemic stroke/Neurological function分类
医药卫生引用本文复制引用
林军,全洁,龙亚德,李志明,谢荣基..替罗非班序贯双联抗血小板治疗在进展性缺血性脑卒中的应用效果[J].中国医学创新,2026,23(21):16-20,5.基金项目
湛江市科技计划项目(2022A01126) （2022A01126）
