摘要
Abstract
Objective:To investigate the application effect of Terbutaline Sulfate combined with Theophylline Glycinate in patients with moderate acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:This retrospective cohort study enrolled 80 patients with moderate AECOPD who were treated at the First People's Hospital of Fuzhou City from June 2023 to June 2025.The patients were divided into a combination therapy group and a monotherapy group by different treatment plan,with 40 cases in each group.Both groups received standard baseline treatment.The monotherapy group was treated with Terbutaline Sulfate,while the combination therapy group received Theophylline Glycinate on the basis of monotherapy group.The treatment duration was 7 days for both groups.Clinical efficacy,pulmonary function parameters[FEV1,FEV1/FVC,and 25%maximum expiratory flow(MEF25%)],arterial blood gas parameters(PaO2,SaO2,PaCO2),acid-base status[pH value,bicarbonate(HCO3-),base excess(BE)],and adverse reactions were compared between the two groups.Result:The overall response rate in the combination therapy group(95.00%)was significantly higher than that in the monotherapy group(77.50%)(P<0.05).After treatment,FEV1,FEV1/FVC and MEF25%in both groups increased compared to before treatment,and the combination therapy group had higher values than the monotherapy group(P<0.05).After treatment,both groups showed an increase in PaO2 and SaO2 compared to before the treatment,the PaO2 and SaO2 in the combination therapy group were higher than those in the monotherapy group,and both groups showed a decrease in PaCO2 compared to before the treatment,the PaCO2 in the combination therapy group was lower than that in the monotherapy group(P<0.05).After treatment,the pH values of both groups increased compared to before treatment,the combination therapy group had higher pH values than the monotherapy group group,and the HCO3-and BE levels in the combination therapy group decreased compared to before treatment(P<0.05).After treatment,there were no statistically significant differences in HCO3-and BE between the two groups(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination therapy of Terbutaline Sulfate and Theophylline Glycinate for patients with moderate AECOPD is effective.It can improve the pulmonary function and blood gas analysis indicators of patients,correct the acid-base balance,and has certain safety.关键词
中度慢性阻塞性肺疾病急性加重期/硫酸特布他林/甘氨酸茶碱Key words
Moderate acute exacerbation of chronic obstructive pulmonary disease/Terbutaline Sulfate/Theophylline Glycinate分类
医药卫生
