浙江农业科学2026，Vol.67Issue(8)：1874-1881,8.DOI:10.16178/j.issn.0528-9017.20260239
饲料中添加胆汁酸和牛磺酸对马口鱼肝脏代谢组的影响
Effect of adding bile acid and taurine in feed on the liver metabolome of Opsariichthys bidens
摘要
Abstract
This study focused on the high-value economic fish species Opsariichthys bidens as the research object.In response to the problems of visceral fat deposition and liver and intestinal health damage caused by unreasonable feed nutrition in its artificial breeding,a control group(commercial feed),a bile acid addition group,and a bile acid and taurine composite addition group were set up for a 56-day breeding experiment.Metabolomics technology was used to analyze the liver metabolites of Opsariichthys bidens.The results showed that both the bile acid addition group and the bile acid-taurine composite addition group could alter the metabolic profile of Opsariichthys bidens liver.Differential metabolites were mainly enriched in pathways related to fat metabolism and digestive system,such as arachidonic acid metabolism,primary bile acid synthesis,and bile secretion.Among them,the addition of bile acid alone inhibited the conversion of cholesterol into bile acid and conjugated bile acid in the liver of Opsariichthys bidens.Adding bile acid-taurine composite can promote the synthesis of free primary bile acids and conjugated bile acids in the liver of Opsariichthys bidens.The above results can provide a theoretical basis for the development of an efficient composite bile acid feed additive formula for Opsariichthys bidens,and solve the problem of nutritional incompatibility in its artificial breeding feed.关键词
胆汁酸/牛磺酸/马口鱼/肝脏/代谢组Key words
bile acid/taurine/Opsariichthys bidens/liver/metabolism分类
农业科技引用本文复制引用
严晶晶,叶伟清,杨庆满,唐金玉,姜青华,梁骁,黄福勇..饲料中添加胆汁酸和牛磺酸对马口鱼肝脏代谢组的影响[J].浙江农业科学,2026,67(8):1874-1881,8.基金项目
杭州市农业科技协作与创新攻关项目(2025TD05) （2025TD05）
2025年绍兴市基础公益专项项目(2025A12001) （2025A12001）
