浙江中医药大学学报2026，Vol.50Issue(7)：863-872,10.DOI:10.16466/j.issn1005-5509.2026.07.006
王笑民教授运用天人合一理论辨治肺癌的用药规律
Medication Rules of Wang Xiaomin in Treating Lung Cancer with"Heaven-Human Unity"Theory
摘要
Abstract
[Objective]To explore Professor Wang Xiaomin's medication patterns for lung cancer based on the temporal dimensions of the four seasons,Six Qi(six climatic factors),and phases of the lunar cycle.[Methods]Prescription data of lung cancer outpatients treated by Professor Wang Xiaomin from December 2007 to December 2023 were retrospectively collected to establish a database using Excel 2021 software.Within Python 3.8.17 environment,an astronomical library was utilized to calculate and assign temporal labels(four seasons,Six Qi and lunar phases)to each prescription.Pearson's chi-square test,Fisher's exact test and Bonferroni correction were applied for global and pairwise comparisons of Chinese herb efficacies and single herbs across different time dimensions.A random forest classifier was constructed to extract key characteristic herbs distinguishing different temporal phases based on Gini importance scores.Furthermore,an agglomerative hierarchical clustering analysis using Ward's minimum variance method was performed on a multidimensional feature space(comprising total frequency and Six Qi coverage),coupled with the silhouette score for automated optimization,to reveal the clustering and compatibility rules of core herbs.[Results]Significant differences were observed in the distribution of core Chinese herb efficacies and herb usages across varied temporal dimensions.At the local"tumor-eliminating"level,the"three methods for tumor-eliminating"(clearing heat and detoxifying,resolving phlegm and dissipating nodules,promoting blood circulation and removing blood stasis)exhibited the highest application proportion during spring when Yang Qi generates,whereas nodule-dissipating herbs were preferred in winter.At the holistic regulation level,medication demonstrated a dynamic evolution aligned with the four seasons and six Qi:Spring treatments focused on soothing the liver and purging the lung;summer primarily featured heat-clearing and swelling-reducing approaches;late summer centered on dampness-dispelling,stomach-harmonizing,Yang-warming and cold-dispersing therapies;autumn emphasized promoting digestion and harmonizing the stomach;and winter prioritized nourishing Yin,clearing heat and generating fluid.Random forest models indicated that wind heat-dispersing,digestion-promoting,heat-cooling and blood-cooling therapies,and herbs like Herba Dendrobii,Bulbus Lilii,and Radix Rehmanniae contributed highest to temporal feature classification.Furthermore,core herbs were classified into 7 clusters,representing distinct spatiotemporal compatibility patterns,including Qi-tonifying and Yin-nourishing,Yin-nourishing and mind-calming,phlegm-resolving and nodule-dissipating,Qi-tonifying and spleen-strengthening,Yang-returning,heat-clearing and detoxifying,liver-soothing and relieving depression.Regarding the lunar-phase treatment,therapy dynamically adapted to the lunar cycle:the new moon phase mainly featured heat-clearing,Yin-nourishing,and fluid-generating approaches,whereas the full moon phase focused on tranquilizing the mind and calming fright.Random forest models identified heat-cooling and mind-tranquilizing efficacies,alongside herbs like Radix Rehmanniae and Concha Ostreae,as the key characteristic indicators for lunar-phase classification.[Conclusion]Professor Wang Xiaomin has organically combined natural rhythms with the occurrence and development of human tumors,and constructed a dynamic diagnosis and treatment model of lung cancer with"local tumor elimination and holistic regulation"based on the changes of the four seasons,Six Qi and lunar phases.Not only has it enriched the modern clinical practice of the theory of correspondence between heaven and human,but it has also provided new ideas for individualized and precise traditional Chinese medicine treatment of lung cancer.关键词
肺癌/天人合一/岩燚理论/用药规律/四时/六气/月相/王笑民Key words
lung cancer/unity of heaven and humanity/"Yan-Yi"theory/medication rules/seasonal variations/six Qi/lunar phases/Wang Xiaomin分类
医药卫生引用本文复制引用
胡紫馨,殷晓辉,丁彤晶,念家云,王笑民..王笑民教授运用天人合一理论辨治肺癌的用药规律[J].浙江中医药大学学报,2026,50(7):863-872,10.基金项目
北京市属医院科研培育计划(PZ2023010) （PZ2023010）
癌症、心脑血管、呼吸和代谢性疾病防治研究国家科技重大专项(2024ZD0521102)Research Cultivation Program of Beijing Municipal Hospitals(PZ2023010) （2024ZD0521102）
National Key Research and Development Program for the Prevention and Control of Cancer,Cardio-Cerebrovascular,Respiratory and Metabolic Diseases(2024ZD0521102) （2024ZD0521102）
