肿瘤综合治疗电子杂志2026，Vol.12Issue(2)：37-43,7.DOI:10.12151/JMCM.2026.02-05
老年胃肠癌患者术前认知功能障碍与术后谵妄的相关性分析
Correlation analysis between preoperative cognitive dysfunction and postoperative delirium in elderly patients with gastrointestinal cancer
摘要
Abstract
Objective To investigate the correlation analysis between preoperative cognitive dysfunction and postoperative delirium(POD)in elderly patients with gastrointestinal cancer.Method The Montreal cognitive assessment(MoCA)scale was used to assess the cognitive function of 120 patients with gastrointestinal cancer at one day before surgery.Based on the results,patients were divided into a cognitive dysfunction group and a normal cognitive function group.According to the results of confusion assessment method,patients were further divided into a POD group and a non-POD group.The clinical data,postoperative hospitalization time and preoperative MoCA score were compared between the two groups.Multivariate logistic regression analysis was performed to analyze the correlation between preoperative cognitive dysfunction and POD in elderly patients with gastrointestinal cancer.Result Among all 120 elderly patients with gastrointestinal cancer,46(38.3%)exhibited cognitive dysfunction before surgery,and 20(16.7%)patients developed POD.All patients of POD recovered smoothly after aggressive treatment and were discharged without perioperative mortality.The incidence of POD and postoperative hospital stay in the cognitive dysfunction group were significantly higher than those in the normal cognitive function group(P＜0.05).The preoperative MoCA scores of patients in the POD group were significantly lower than those in the non-POD group,while their postoperative hospital stay was significantly longer than that of the non-POD group(P＜0.05).The preoperative MoCA scores,proportion of married patients,preoperative blood Hb,Alb,and Ca2+levels in the POD group were significantly lower than those in the non-POD group,while postoperative hospitalization duration,age,operation duration,proportion of alcohol consumption history,intraoperative hypotension and hypoxia in the POD group were significantly higher than in the non-POD group(P＜0.05).Multivariate logistic regression analysis indicated that preoperative MoCA scores,serum albumin levels,and intraoperative hypoxia were independently associated with POD in elderly patients with gastrointestinal cancer(P＜0.05).Conclusion There is a close correlation between preoperative cognitive dysfunction and the occurrence of POD in elderly patients with gastrointestinal cancer.Higher the preoperative MoCA scale scores may reduce the risk of POD,which deserves clinical attention.关键词
术后谵妄/认知功能障碍/老年/胃肠癌/蒙特利尔认知功能评估量表Key words
Postoperative delirium/Cognitive dysfunction/Elderly/Gastrointestinal cancer/Montreal cognitive assessment scale引用本文复制引用
邓莉健,王玉华,徐金玉,陆常玉,莫炜烈..老年胃肠癌患者术前认知功能障碍与术后谵妄的相关性分析[J].肿瘤综合治疗电子杂志,2026,12(2):37-43,7.基金项目
2023年常州市卫健委科技项目(第二批)(QN202378) （第二批）
