肿瘤综合治疗电子杂志2026，Vol.12Issue(2)：77-85,9.DOI:10.12151/JMCM.2026.02-10
大鼠肉瘤病毒癌基因抑制剂在消化系统肿瘤中的研究进展
Progress of Ras inhibitors in gastrointestinal tumors
张嘉欣 1王雪萌 1姚光宇 1王晰程 1巴一1
作者信息
- 1. 中国医学科学院北京协和医院 肿瘤医学中心,北京 100021
- 折叠
摘要
Abstract
The rat sarcoma viral oncogene family(Ras)is among the most common oncogenic drivers in gastrointestinal malignancies,playing a pivotal role in colorectal cance,pancreatic ductal adenocarcinoma,and other cancers.Owing to the unique structural features of Ras proteins and the complexity of their downstream signaling networks,Ras had long been considered an"undruggable"target.In recent years,the successful approval of KRAS G12C inhibitors has broken this paradigm and accelerated the development of inhibitors targeting other mutations such as G12D,as well as pan-Ras strategies and combination therapies.However,therapeutic resistance remains a major clinical challenge.This review summarizes the mechanisms of action and clinical progress of Ras inhibitors,discusses their potential as monotherapy and in combination regimens in gastrointestinal tumors,and highlights future directions,including novel allosteric inhibitors,targeted protein degradation,and biomarker-guided strategies,with the aim of informing optimized clinical treatment.关键词
大鼠肉瘤病毒癌基因抑制剂/消化道肿瘤/靶向治疗Key words
Ras inhibitors/Gastrointestinal tumors/Targeted therapy引用本文复制引用
张嘉欣,王雪萌,姚光宇,王晰程,巴一..大鼠肉瘤病毒癌基因抑制剂在消化系统肿瘤中的研究进展[J].肿瘤综合治疗电子杂志,2026,12(2):77-85,9.
