安徽医科大学学报2026，Vol.61Issue(7)：1277-1282,6.DOI:10.19405/j.cnki.issn1000-1492.2026.07.016
人流后应用雌孕激素对胚物残留及宫腔粘连的疗效分析
Efficacy of estrogen and progesterone in preventing retained products of conception and intrauterine adhesions after induced abortion
摘要
Abstract
Objective To evaluate the efficacy of immediate postoperative oral administration of 2 mg estradiol/es-tradiol dydrogesterone tablets in reducing secondary surgery for retainedproducts of conception(RPOC),prevent-ing intrauterine adhesions(IUA),and promoting endometrial repair following induced abortion.Methods A retro-spective analysis was conducted on 494 patients who underwent induced abortion.The control group(n=214)re-ceived conventional postoperative treatment with antibiotics and Yimucao granules,while the observation group(n=280)received immediate administration of estradiol/dydrogesterone tablets(each tablet contains 2 mg of estra-diol),combined with antibiotics and Yimucao granules.The two groups were compared for the secondary surgery rate for RPOC,incidence of IUA,endometrial thickness at 2 weeks postoperatively,duration of postoperative vagi-nal bleeding,time to menstrual resumption,incidence of reduced menstrual volume after resumption,and postop-erative complications(pelvic infection,intrauterine fluid accumulation).Results The observation group showed a lower rate of secondary surgery for RPOC compared to the control group(0.4％vs 2.3％),but the difference was not statistically significant(P=0.13,Fisher's exact test).The observation group also had a significantly lower in-cidence of IUA(P＜0.05),greater postoperative endometrial thickness at 2 weeks(P＜0.05),and significantly shorter duration of postoperative vaginal bleeding and time to menstrual resumption.The incidence of reduced men-strual volume postoperatively and complications(pelvic infection,intrauterine fluid accumulation)were also sig-nificantly lower in the observation group(all P＜0.05).Conclusion Immediate oral administration of estradiol/dydrogesterone tablets after induced abortion significantly prevents intrauterine adhesions,shortens postoperative vaginal bleeding duration,promotes endometrial repair,improves menstrual recovery,and potentially reduces the risk of secondary surgery for retained products of conception.关键词
人工流产/雌二醇片/雌二醇地屈孕酮片/胚物残留/子宫粘连/子宫内膜修复/月经恢复Key words
induced abortion/estradiol/dydrogesterone tablets/retained products of conception/intrauterine ad-hesions/endometrial repair/menstrual recovery分类
医药卫生引用本文复制引用
谢迎艳,张李松,黄晓武,李晓雨,杨雪..人流后应用雌孕激素对胚物残留及宫腔粘连的疗效分析[J].安徽医科大学学报,2026,61(7):1277-1282,6.基金项目
北京市教育委员会科研计划项目(编号:KM202410025009) R&D Program of Beijing Municipal Education Commission(No.KM202410025009) （编号:KM202410025009）
